反应条件
1: 47 percent / N,N-dimethylaniline, N,N-diisopropylethylamine / 18 h / Heating
2: N,N-dimethylaniline, POCl3 / 1,2-dichloro-ethane / 0.5 h / Heating
3: 98 percent / BBr3 / CH2Cl2; 1,2-dichloro-ethane / 2 h / Heating
4: 72 percent / tetrahydrofuran; methanol / 88 h / 60 °C
5: 70 percent / N,N-diisopropylethylamine / 1,2-dichloro-ethane / 1.5 h / 60 °C
View Scheme
参考文献
Capps, David B.; Dunbar, James; Kesten, Suzanne R.; Shillis, Joan; Werbel, Leslie M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 26 p. 4770 - 4778
