[6-羟基-2-(4-羟基苯基)苯并[b]噻吩-3-基][4-[2-(1-吡咯烷基)乙氧基]苯基]-甲酮合成路线 （共 13 条）
反应条件
sodium hydroxide in methanol
2 h; Ambient temperature;
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
sodium hydroxide in tetrahydrofuran; methanol
60 h; Ambient temperature;
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
methanesulfonic acid; water in ethanol
72 h; Heating; Yield given;
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
3: 71 percent / pyridine hydrochloride / 6 h / 220 °C
4: 97 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
5: AlCl3 / 1,2-dichloro-ethane / 1 h
6: 5 N NaOH / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 71 percent / pyridine hydrochloride / 6 h / 220 °C
2: 97 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
3: AlCl3 / 1,2-dichloro-ethane / 1 h
4: 5 N NaOH / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 97 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
2: AlCl3 / 1,2-dichloro-ethane / 1 h
3: 5 N NaOH / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: AlCl3 / 1,2-dichloro-ethane / 1 h
2: 5 N NaOH / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 69 percent / PPA / 1 h / 85 - 90 °C
2: 71 percent / pyridine hydrochloride / 6 h / 220 °C
3: 97 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
4: AlCl3 / 1,2-dichloro-ethane / 1 h
5: 5 N NaOH / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: SOCl2, DMF / 1,2-dichloro-ethane / 2 h / Heating
2: AlCl3 / 1,2-dichloro-ethane / 1 h
3: 5 N NaOH / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
3: 71 percent / pyridine hydrochloride / 6 h / 220 °C
4: 97 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature
5: AlCl3 / 1,2-dichloro-ethane / 1 h
6: 5 N NaOH / methanol / 2 h / Ambient temperature
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
