1-(4-甲氧基苯基)-2-(3-甲氧基苯硫基)乙酮合成路线 （共 18 条）
反应条件
potassium hydroxide in ethanol; water T=20°C; 18 h; Inert atmosphere;
参考文献
Rey, Jullien; Hu, Haipeng; Kyle, Fiona; Lai, Chun-Fui; Buluwela, Laki; Coombes, R. Charles; Ortlund, Eric A.; Ali, Simak; Snyder, James P.; Barrett, Anthony G. M.
ChemMedChem, 2012 , vol. 7, # 11 p. 1909 - 1914
反应条件
1: 3-methoxy-benzenethiol With sodium methylate in methanol T=35°C; 2: 4-methoxyphenyl chloromethyl ketone in methanol T=0 - 35°C; 1.16667 h;
参考文献
BASF AKTIENGESELLSCHAFT
Patent: WO2005/42477 A1, 2005 ;
Location in patent: Page/Page column 4 ;
反应条件
potassium hydroxide in ethanol; water; Petroleum ether
参考文献
ELI LILLY AND COMPANY
Patent: EP819686 A1, 1998 ;
反应条件
1: 1-(4-methoxyphenyl)ethanone With sulfuryl dichloride in toluene; butan-1-ol T=25 - 30°C; 0.5 h; 2: With sodium hydroxide; water in toluene; butan-1-ol T=30°C; 3: 3-methoxy-benzenethiol With sodium hydroxide T=0 - 5°C; 1.5 h; Product distribution / selectivity;
参考文献
BASF AKTIENGESELLSCHAFT
Patent: WO2004/78705 A1, 2004 ;
Location in patent: Page/Page column 4-5 ;
反应条件
hydridotetrakis(triphenylphosphine)rhodium (Ph3P)4RhH; 1,2-bis-(diphenylphosphino)ethane in tetrahydrofuran 1 h; Inert atmosphereReflux;
参考文献
Arisawa, Mieko; Toriyama, Fumihiko; Yamaguchi, Masahiko
Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 10 p. 1349 - 1352
反应条件
1: 69 percent / PPA / 1 h / 85 - 90 °C 2: 71 percent / pyridine hydrochloride / 6 h / 220 °C 3: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature 4: 93 percent / trifluoromethanesulfonic acid / 1,2-dichloro-ethane / Heating 5: 42 percent / 5 N aq. NaOH / ethanol / 1.5 h / Heating View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 69 percent / PPA / 1 h / 85 - 90 °C 2: AlCl3 / CH2Cl2 / 1.5 h / 27 - 29 °C 3: 77.5 percent / AlCl3, EtSH / CH2Cl2 / 0.5 h / Ambient temperature View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 69 percent / PPA / 1 h / 85 - 90 °C 2: 71 percent / pyridine hydrochloride / 6 h / 220 °C View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: in toluene P=760.051 Torr; 2 h; RefluxInert atmosphereDean-StarkLarge scale; 2: With methanesulfonic acid in toluene T=90°C; 4 h; Inert atmosphereLarge scale; 3: in n-heptane; toluene T=80 - 90°C; 4 h; Inert atmosphereLarge scale; Reagent/catalystSolventTemperature;
参考文献
Vicenzi, Jeffrey T.; Zhang, Tony Y.; Robey, Roger L.; Alt, Charles A.
Organic Process Research and Development, 1999 , vol. 3, # 1 p. 56 - 59
