N6-Cbz-L-赖氨酸苄酯盐酸盐合成路线 （共 7 条）
反应条件
hydrogenchloride in ethyl acetate T=20°C; 1 h;
参考文献
Kulikov, S. V.; Leonova, E. B.; Kalinina, N. M.; Samartsev, M. A.; Bubnova, L. N.; et al.
Russian Journal of Bioorganic Chemistry, 1995 , vol. 21, # 6 p. 362 - 369
Bioorganicheskaya Khimiya, 1995 , vol. 21, # 6 p. 421 - 429
反应条件
hydrogenchloride; sodium hydroxide; N2; toluene-4-sulfonic acid; benzyl alcohol in water; toluene
反应条件
1.1: aq. Cs2CO3 / ethanol / 1 h / 20 °C 1.2: 99 percent / dimethylformamide / 16 h / 50 °C 2.1: HCl / ethyl acetate / 3 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 13 p. 4285 - 4292
反应条件
1: T=20 - 90°C; 2: With sodium carbonate in water pH=10; 3: With hydrogenchloride in diethyl ether
参考文献
Bioorganic and Medicinal Chemistry, , vol. 18, # 17 p. 6220 - 6229
反应条件
1.1: aq. Cs2CO3 / ethanol / 1 h / 20 °C 1.2: 99 percent / dimethylformamide / 16 h / 50 °C 2.1: HCl / ethyl acetate / 3 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 13 p. 4285 - 4292
反应条件
1: 91 percent / Et3N / CH2Cl2 / 1.5 h / 0 °C 2: 82 percent / NaOH / dimethylformamide / 1 h / 20 °C View Scheme
参考文献
Yoshioka, Tadao; Krauser, Joel A; Guengerich, F Peter
Chemical research in toxicology, 2002 , vol. 15, # 8 p. 1096 - 1105
反应条件
1: BOC-glycine; 1-hydroxy-pyrrolidine-2,5-dione With triethylamine in dichloromethane
0.333333 h;
2: H-Lys(Z)-OBzl*HCl With dicyclohexyl-carbodiimide in dichloromethane
72 h;
参考文献
Lehmann, Lutz; Friebe, Matthias; Brumby, Thomas; Suelzle, Detlev; Platzek, Johannes
Patent: US2004/208828 A1, 2004 ;
Location in patent: Page 16 ;
