1-乙炔基-3,5-二甲基苯合成路线 （共 10 条）
反应条件
1: 1-(3,5-dimethylphenyl)acetylene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.25 h;
2: N-methyl-N-methoxy-2-[(3-phenylprop-2-yn-1-yl)oxy]acetamide in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Wessig, Pablo; Mueller, Gunnar; Herre, Robert; Kuehn, Andreas
Helvetica Chimica Acta, 2006 , vol. 89, # 11 p. 2694 - 2719
反应条件
potassium carbonate in dichloromethane; acetonitrile
T=20°C;
参考文献
Thevenin, Marion; Thoret, Sylviane; Grellier, Philippe; Dubois, Joelle
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 4885 - 4892
反应条件
potassium carbonate in methanol
T=4°C; Horner-Wadsworth-Emmons reaction; 96 h;
参考文献
Barrett, Anthony G. M.; Hopkins, Brian T.; Love, Andrew C.; Tedeschi, Livio
Organic Letters, 2004 , vol. 6, # 5 p. 835 - 837
反应条件
1: With copper(l) iodide; bis(benzonitrile)palladium(II) dichloride in methanol
2: With potassium carbonate in methanol
参考文献
Trost; Pinkerton
Tetrahedron Letters, 2000 , vol. 41, # 49 p. 9627 - 9631
反应条件
potassium phosphate; potassium hydroxide in toluene
Inert atmosphereReflux;
参考文献
Smeyanov, Alexey; Schmidt, Andreas
Synthetic Communications, 2013 , vol. 43, # 20 p. 2809 - 2816
反应条件
1: 100 percent Chromat. / diethylamine; PPh3; CuI / PdCl2 / heptane / Heating
2: Darco G-60; sodium tert-butoxide / heptane / 2 h / Heating
View Scheme
参考文献
Farr, Roger N.; Alabaster, Ramon J.; Chung, John Y.L.; Craig, Bridgette; Edwards, John S.; Gibson, Andrew W.; Ho, Guo-Jie; Humphrey, Guy R.; Johnson, Simon A.; Grabowski
Tetrahedron Asymmetry, 2003 , vol. 14, # 22 p. 3503 - 3515
反应条件
1: 98 percent / triethylamine; bis(triphenylphosphine)palladium dichloride; copper(I) iodide / 4 h / 20 °C
2: 80 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / -15 °C
View Scheme
参考文献
Marchand, Pascal; Puget, Alain; Le Baut, Guillaume; Emig, Peter; Czech, Michael; Guenther, Eckhard
Tetrahedron, 2005 , vol. 61, # 16 p. 4035 - 4041
反应条件
2: PCl3 / benzene
3: NaNH2, NH3
View Scheme
参考文献
Tinnemans,A.H.A.; Laarhoven,W.H.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1976 , p. 1104 - 1111
反应条件
1: PCl3 / benzene
2: NaNH2, NH3
View Scheme
参考文献
Tinnemans,A.H.A.; Laarhoven,W.H.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1976 , p. 1104 - 1111
反应条件
ammonia; sodium amide
参考文献
Tinnemans,A.H.A.; Laarhoven,W.H.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1976 , p. 1104 - 1111
