1: 4.3 mg / EDCI; DMAP / dimethylformamide / 16 h / 25 °C 2: 98 percent / aq. LiOH / tetrahydrofuran; methanol / 8 h / 60 °C 3: EDCI; DMAP / dimethylformamide / 14 h / 25 °C 4: HCl / ethanol / 2.5 h / 0 - 25 °C 5: NH3 / ethanol / 1 h / 25 °C 6: methanol; tetrahydrofuran / 1 h / -40 °C View Scheme

1: 4.3 mg / EDCI; DMAP / dimethylformamide / 16 h / 25 °C 2: 98 percent / aq. LiOH / tetrahydrofuran; methanol / 8 h / 60 °C 3: EDCI; DMAP / dimethylformamide / 14 h / 25 °C 4: HCl / ethanol / 2.5 h / 0 - 25 °C 5: NH3 / ethanol / 1 h / 25 °C 6: methanol; tetrahydrofuran / 1 h / -40 °C View Scheme

1: EDCI; DMAP / dimethylformamide; CH2Cl2 / 18 h / 25 °C 2: HCl / ethyl acetate / 2 h / 25 °C 3: 4.3 mg / EDCI; DMAP / dimethylformamide / 16 h / 25 °C 4: 98 percent / aq. LiOH / tetrahydrofuran; methanol / 8 h / 60 °C 5: EDCI; DMAP / dimethylformamide / 14 h / 25 °C 6: HCl / ethanol / 2.5 h / 0 - 25 °C 7: NH3 / ethanol / 1 h / 25 °C 8: methanol; tetrahydrofuran / 1 h / -40 °C View Scheme

1: NH3 / ethanol / 1 h / 25 °C 2: methanol; tetrahydrofuran / 1 h / -40 °C View Scheme

1: HCl / ethyl acetate / 2 h / 25 °C 2: 4.3 mg / EDCI; DMAP / dimethylformamide / 16 h / 25 °C 3: 98 percent / aq. LiOH / tetrahydrofuran; methanol / 8 h / 60 °C 4: EDCI; DMAP / dimethylformamide / 14 h / 25 °C 5: HCl / ethanol / 2.5 h / 0 - 25 °C 6: NH3 / ethanol / 1 h / 25 °C 7: methanol; tetrahydrofuran / 1 h / -40 °C View Scheme

1: EDCI; DMAP / dimethylformamide / 14 h / 25 °C 2: HCl / ethanol / 2.5 h / 0 - 25 °C 3: NH3 / ethanol / 1 h / 25 °C 4: methanol; tetrahydrofuran / 1 h / -40 °C View Scheme

1: 98 percent / aq. LiOH / tetrahydrofuran; methanol / 8 h / 60 °C 2: EDCI; DMAP / dimethylformamide / 14 h / 25 °C 3: HCl / ethanol / 2.5 h / 0 - 25 °C 4: NH3 / ethanol / 1 h / 25 °C 5: methanol; tetrahydrofuran / 1 h / -40 °C View Scheme

1: HCl / ethanol / 2.5 h / 0 - 25 °C 2: NH3 / ethanol / 1 h / 25 °C 3: methanol; tetrahydrofuran / 1 h / -40 °C View Scheme

in tetrahydrofuran; methanol T=-40°C; 1 h;

sodium hydrogencarbonate in 1,4-dioxane; water 1.) RT, 1 h, 2.) 40 deg C, 2 h;