2-氨基-4-氯-6-硝基苯酚合成路线 （共 14 条）
反应条件
hydrogenchloride in propan-1-ol; water T=0 - 30°C; 4 h; Heating / reflux;
参考文献
Eijgendaal, Irene; Klein, Gerrit; Terhorst-Van Amstel, Maria J.L.; Zwier, Klaas; Bruins, Nico; Rigter, Hendrikus T.; Gout, Erik
Patent: US2006/40932 A1, 2006 ;
Location in patent: Page/Page column 4-5 ;
反应条件
2: nitric acid / 25 - 50 °C 3: diluted NaOH-solution View Scheme
参考文献
DE234742 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 10, p. 136
反应条件
1: nitric acid / 25 - 50 °C 2: diluted NaOH-solution View Scheme
参考文献
DE234742 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 10, p. 136
反应条件
durch partielle Reduktion;
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C 2: hydrogen / palladium 10 on activated carbon / N,N-dimethyl-formamide; tetrahydrofuran; methanol / 3102.97 Torr View Scheme
参考文献
PHARMESTE S.R.L.; NAPOLETANO, Mauro; TREVISANI, Marcello; PAVANI, Maria Giovanna; FRUTTAROLO, Francesca
Patent: WO2011/120604 A1, 2011 ;
WO 2011/120604 A1
Title/Abstract Full Text Show Details
Pharmeste S.r.l.
Patent: EP2377850 A1, 2011 ;
反应条件
1: ethyl acetate / 2 h 2: hydrogen / palladium 10 on activated carbon / N,N-dimethyl-formamide; methanol / 3102.97 Torr View Scheme
参考文献
WO2011/120604 A1, ;
WO 2011/120604 A1
反应条件
in ethyl acetate T=20 - 25°C; 2 h;
参考文献
Eijgendaal, Irene; Klein, Gerrit; Terhorst-Van Amstel, Maria J.L.; Zwier, Klaas; Bruins, Nico; Rigter, Hendrikus T.; Gout, Erik
Patent: US2006/40932 A1, 2006 ;
Location in patent: Page/Page column 5 ;
参考文献
I. G. Farbenind.
Patent: DE487014 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 431
反应条件
1: With di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=-10 - 20°C; 18 h; 2: With hydrogenchloride in ethanol; water
参考文献
Solvay Pharmaceuticals B.V.
Patent: EP1212320 B1, 2005 ;
Location in patent: Page/Page column 6; 8-9 ;
EP 1212320 B1
