2,4-二氯-5-苯基嘧啶合成路线 （共 3 条）
反应条件
triethyl amine hydrochloride; trichlorophosphate
T=120°C; 72 h; Heating / reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/37814 A1, 2004 ;
Location in patent: Page 180-181 ;
WO 2004/037814 A1
反应条件
[1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride; potassium carbonate in N,N-dimethyl-formamide; toluene
T=185°C; Suzuki cross-coupling; 0.166667 h; Irradiation;
参考文献
Ceide, Susana Conde; Montalban, Antonio Garrido
Tetrahedron Letters, 2006 , vol. 47, # 26 p. 4415 - 4418
反应条件
1: urea; aq. NaOH solution
2: POCl3
View Scheme
参考文献
Davies; Piggott
Journal of the Chemical Society, 1945 , p. 347 Anm.
