(S)-1,2,3,4-四氢喹啉-2-羧酸甲酯合成路线 （共 8 条）
反应条件
(R)-(-)-5,5'-bis(diphenylphosphino)-2,2,2',2'-tetrafluoro-4,4'-bi-1,3-benzodioxole; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; hydrogen; iodine in toluene T=20°C; P=37503.8 Torr; 17 h; Autoclave; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Letters, , vol. 53, # 35 p. 4747 - 4750
反应条件
α-chymotrypsine T=30°C; pH=7.4 - 7.5; 72 h; Resolution of racemateSoerensen-bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
Kannenberg, Axel; Rost, Daniel; Eibauer, Stefan; Tiede, Sascha; Blechert, Siegfried
Angewandte Chemie - International Edition, 2011 , vol. 50, # 14 p. 3299 - 3302
反应条件
1: H2 / PtO2 / methanol 2: SOCl2 View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 24 p. 4295 - 4299
反应条件
Pseudomonas cepacia lipase in tetrahydrofuran T=30°C; 30 h; Inert atmosphereResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 21, # 18 p. 2307 - 2313
反应条件
Candida antarctica lipase B in tetrahydrofuran T=30°C; 30 h; Inert atmosphereResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 21, # 18 p. 2307 - 2313
反应条件
1: platinum(IV) oxide; hydrogen / methanol / 45004.5 - 52505.3 Torr 2: α-chymotrypsine / 72 h / 30 °C / pH 7.4 - 7.5 / Resolution of racemate; Soerensen-buffer; Enzymatic reaction View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 14 p. 3299 - 3302
反应条件
1: Irradiation 2: (R)-(-)-5,5'-bis(diphenylphosphino)-2,2,2',2'-tetrafluoro-4,4'-bi-1,3-benzodioxole; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; hydrogen; iodine / toluene / 17 h / 20 °C / 37503.8 Torr / Autoclave View Scheme
参考文献
Tetrahedron Letters, , vol. 53, # 35 p. 4747 - 4750
反应条件
1: SOCl2 View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 24 p. 4295 - 4299
