4-(4-溴苯基)吗啉-3-酮合成路线 (共 2 条)
反应条件
dipotassium hydrogenphosphate; copper(l) iodide; N-methyl-2-(methylamino)ethylamine in 1,4-dioxane
T=105°C; 15 h; Inert atmosphereSealed tube;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; WROBLESKI, Stephen T.; JAGABANDHU, Das; DOWEYKO, Lidia M.; GUO, Junqing; HYNES, John; JIANG, Bin; KEMPSON, James; LIN, Shuqun; SPERGEL, Steven H.; TOKARSKI, John S.; WU, Hong; YANG, Bingwei Vera
Patent: WO2012/125887 A1, 2012 ;
Location in patent: Page/Page column 128-129 ;
WO 2012/125887 A1
反应条件
potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride in dichloromethane
5 h; Heating / reflux;
参考文献
BAYER HEALTHCARE AG
Patent: WO2003/104227 A1, 2003 ;
Location in patent: Page 53 ;