1-(二苯甲基氨基)-3-氯丙烷-2-醇合成路线 （共 6 条）
反应条件
1: N-ethyl-N,N-diisopropylamine / ethanol / 0 - 90 °C 2: triethylamine / dichloromethane / 1 h / 0 °C View Scheme
参考文献
Metkar, Shashikant D.; Bhatia, Manish S.; Desai, Uday V.
Medicinal Chemistry Research, 2013 , vol. 22, # 12 p. 5982 - 5989
反应条件
1: triethylamine / acetonitrile / 49 h / |Reflux 2: triethylamine / dichloromethane / 1 h / 0 - 5 °C 3: sodium azide / N,N-dimethyl-formamide / 90 °C 4: ammonium chloride; zinc / ethanol; water / 7 h / |Reflux View Scheme
参考文献
Metkar, Shashikant D.; Bhatia, Manish S.; Desai, Uday V.
Medicinal Chemistry Research, 2013 , vol. 22, # 12 p. 5982 - 5989
反应条件
in dimethyl sulfoxide T=50°C;
参考文献
Isoda, Takeshi; Ushirogochi, Hideki; Satoh, Koichi; Takasaki, Tsuyoshi; Yamamura, Itsuki; Sato, Chisato; Mihira, Ado; Abe, Takao; Tamai, Satoshi; Yamamoto, Shigeki; Kumagai, Toshio; Nagao, Yoshimitsu
Journal of Antibiotics, 2006 , vol. 59, # 4 p. 241 - 247
反应条件
N-ethyl-N,N-diisopropylamine in ethanol T=0 - 90°C;
参考文献
WO2013/14448 A1, ;
Page/Page column 96 ;
WO 2013/014448 A1
反应条件
in methanol
T=0 - 20°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie
Patent: WO2013/14448 A1, 2013 ;
Location in patent: Page/Page column 96 ;
WO 2013/014448 A1
反应条件
1: N-ethyl-N,N-diisopropylamine / ethanol / 0 - 90 °C
2: triethylamine / dichloromethane / 1 h / 0 °C
3: water; acetonitrile / 100 °C
View Scheme
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; FINLAY, Maurice, Raymond, Verschoyle; WARD, Richard, Andrew; KADAMBAR, Vasantha, Krishna; CHANDRASHEKAR, Reddy, C.; MURUGAN, Andiappan; REDFEARN, Heather, Marie
Patent: WO2013/14448 A1, 2013 ;
WO 2013/014448 A1
