反应条件
1: 79 percent / bromine, sodium acetate / acetic acid / Ambient temperature; 1.) 22 h, 2.) 24 h, 3.) 20 h
2: 71 percent / NaOMe / tetrahydrofuran; methanol / 1.) -5 deg C, 5 h, 2.) 4 deg C, 48 h
3: xylene / 1 h / Heating
4: LiAlH4 / diethyl ether / 1.) 4 h, reflux, 2.) overnight, RT
5: 84 percent / MnO2 / CH2Cl2 / 0.75 h / Heating
6: 70 percent / Rh(PPh3P)2CO(Cl), 1,3-bis(diphenylphosphino)propane / 1,3,5-trimethyl-benzene / 1.3 h / Heating
7: 1.) 1.8 M t-butyl-lithium / 1.) THF, hexane, -78 deg C, 1 h; 2.) THF, hexane, -78 deg C, 1 h
View Scheme
参考文献
Bolton, Richard E.; Moody, Christopher, J.; Rees, Charles W.; Tojo, Gabriel
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 931 - 936
