5-硝基-1-苯并噻吩-2-羧酸合成路线 （共 29 条）
反应条件
water; sodium hydroxide in tetrahydrofuran T=20°C; 6 h;
参考文献
Cai, Jin; Zhang, Shaoning; Zheng, Ming; Wu, Xiaoqing; Chen, Junqing; Ji, Min
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 806 - 810
反应条件
potassium hydroxide in ethanol T=20°C; 3 h;
参考文献
Pessoa-Mahana, Hernan; Kosche C., Johann; Ron H., Nadia; Recabarren-Gajardo, Gonzalo; Saitz B., Claudio; Araya-Maturana, Ramiro; Pessoa-Mahana, C. David
Heterocycles, 2008 , vol. 75, # 8 p. 1913 - 1929
反应条件
ethanol; disodium disulfide anschliessend Erwaermen mit Natriumsulfid und wss. Natronlauge und Erwaermen des Reaktionsgemisches mit Natrium-chloracetat in Wasser;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 527, p. 83,101
Journal of the American Chemical Society, , vol. 77, p. 5539,5941
参考文献
Justus Liebigs Annalen der Chemie, , vol. 527, p. 83,101
反应条件
1: Na2S; Na2CO3; aqueous ethanol / Erhitzen der Reaktionsloesung mit wss.Natrium-chloracetat-Loesung 2: aq. NaOH solution View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 527, p. 83,101
反应条件
copper in benzopyrazine T=170 - 190°C; 0.666667 h;
参考文献
AMGEN, INC.
Patent: WO2006/66172 A1, 2006 ;
Location in patent: Page/Page column 27 ;
WO 2006/066172 A1
反应条件
1: 65 percent / Cu / quinoline / 0.5 h / 190 °C 2: 95 percent / H2 / 5percent Pd/C / ethanol / 1.5 h / 2280 Torr 3: 59.6 percent / conc. H2SO4, NaNO2 / 0.5 h / 0 - 10 °C View Scheme
参考文献
Martin-Smith; Gates
Journal of the American Chemical Society, 1956 , vol. 78, p. 5351,5354
反应条件
1: copper; quinoline 2: chloroform; bromine View Scheme
参考文献
Bordwell; Albisetti
Journal of the American Chemical Society, 1948 , vol. 70, p. 1955,1957
反应条件
1: iron (II)-sulfate; aqueous ammonia 2: lead (II)-oxide / 480 °C 3: aqueous sulfuric acid; sodium nitrite / aus Diazoniumsalz-Loesung 4: alkaline solution View Scheme
参考文献
Fries et al.
Justus Liebigs Annalen der Chemie, 1937 , vol. 527, p. 83,101
