alpha-甲基-4-联苯乙酸合成路线 （共 34 条）
反应条件
1.1: 42 percent / (Me2N)3P=NP(NMe2)2=NEt / tetrahydrofuran / 20 °C 2.1: Mg; HgCl2 / methanol / 24 h / 20 °C 2.2: 38 percent / KOH / methanol / 24 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 67, # 15 p. 5216 - 5225
反应条件
1.1: (ortho-HON=CMeC6H4PdCl)2; K2CO3 / dimethylformamide / 12 h / 120 °C 1.2: 54 percent / BuLi; HMPA / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 42 percent / (Me2N)3P=NP(NMe2)2=NEt / tetrahydrofuran / 20 °C 3.1: Mg; HgCl2 / methanol / 24 h / 20 °C 3.2: 38 percent / KOH / methanol / 24 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 67, # 15 p. 5216 - 5225
反应条件
1.1: H2SO4 / 4 h / Heating 2.1: LDA / tetrahydrofuran / 0.5 h / 0 °C 2.2: tetrahydrofuran / 0.5 h / -78 °C 3.1: NaOH / H2O / 2 h / Heating View Scheme
参考文献
Chemical Research in Toxicology, , vol. 10, # 1 p. 91 - 102
反应条件
1.1: LDA / tetrahydrofuran / 0.5 h / 0 °C 1.2: tetrahydrofuran / 0.5 h / -78 °C 2.1: NaOH / H2O / 2 h / Heating View Scheme
参考文献
Chemical Research in Toxicology, , vol. 10, # 1 p. 91 - 102
反应条件
bis(triphenylphosphine)palladium(O) in tetrahydrofuran
参考文献
Tetrahedron Letters, , vol. 34, # 33 p. 5333 - 5336
反应条件
1: NaHSO3 / methanol; H2O 2: DMSO, Ac2O / 24 h / Ambient temperature 3: K2CO3 / H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 27, # 34 p. 3995 - 3998
反应条件
1: DMSO, Ac2O / 24 h / Ambient temperature 2: K2CO3 / H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 27, # 34 p. 3995 - 3998
反应条件
1: NaBH4, 0.9N NaOH 2: 2N HCl / 10 h / Heating 3: 88 percent / H2SO4 / benzene 4: 26 percent / 0.5N EtONa / ethanol / 1 h / Ambient temperature 5: 80 percent / pyridinium chloride / 0.67 h / 220 °C View Scheme
参考文献
Gazzetta Chimica Italiana, , vol. 115, # 4 p. 199 - 216
反应条件
1.1: copper(l) chloride; sodium t-butanolate / tetrahydrofuran / 0.17 h / 20 °C 1.2: 20 - 65 °C 2.1: potassium tert-butylate / tetrahydrofuran; toluene / 3 h / -78 - 20 °C / 760.05 Torr View Scheme
参考文献
Chemistry - A European Journal, , vol. 18, # 30 p. 9391 - 9396
反应条件
1.1: potassium carbonate / 1,4-dioxane / 16 h / Reflux 2.1: (C5H3N)(MeC=N(C6H4-2,6-iPr2))2; ethylmagnesium bromide; iron(II) chloride / tetrahydrofuran; diethyl ether / 2 h / 20 °C / Inert atmosphere 2.2: 0.5 h / Inert atmosphere View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 29 p. 11900 - 11903
