1,2,3-三甲氧基苯合成路线 （共 210 条）
反应条件
1: 92 percent / pyridinium tribromide; FeCl3*6H2O; acetic anhydride / 0.08 h / 55 °C
2: 63 percent / tetrabutylammonium fluoride / Pd(dba)2 / dimethylformamide; tetrahydrofuran / 12 h / 90 °C
View Scheme
参考文献
Banwell, Martin G.; Cameron, Jennifer M.; Corbett, Madeline; Dupuche, Joseph R.; Hamel, Ernest; et al.
Australian Journal of Chemistry, 1992 , vol. 45, # 12 p. 1967 - 1982
反应条件
1: boron trifluoride diethyl etherate; trifluoroacetic anhydride / 1,2-dichloro-ethane / 18 h / |Reflux
2: potassium carbonate / acetone / 18 h / |Reflux
View Scheme
参考文献
Stocker, Vivien; Ghinet, Alina; Leman, Marie; Rigo, Benoit; Millet, Regis; Farce, Amaury; Desravines, Deborah; Dubois, Joelle; Waterlot, Christophe; Gautret, Philippe
RSC Advances, 2013 , vol. 3, # 11 p. 3683 - 3696
反应条件
1: 81 percent / ZnCl2 / propionic acid / Heating
2: 98 percent / K2CO3
View Scheme
参考文献
Jing, Xiaobi; Gu, Wenxin; Bie, Pingyan; Ren, Xinfeng; Pan, Xinfu
Synthetic Communications, 2001 , vol. 31, # 6 p. 861 - 867
反应条件
1: POCl3
3: KHSO4
View Scheme
参考文献
Sapewalowa; Koton
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 2900,2902; engl. Ausg. S. 2860, 2862
反应条件
1: With aluminium trichloride
T=20°C; Acylation; demethylation; ethylation; 22 h;
2: With piperidine in water
Cyclization; 47 h; Heating;
参考文献
Fernandes, Eduarda G. R.; Silva, Artur M. S.; Cavaleiro, Jose A. S.; Silva, Francisco M.; Borges, M. Fernanda M.; Pinto, Madalena M. M.
Magnetic Resonance in Chemistry, 1998 , vol. 36, # 4 p. 305 - 309
反应条件
1: POCl3
View Scheme
参考文献
Sapewalowa; Koton
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 2900,2902; engl. Ausg. S. 2860, 2862
反应条件
1: AlCl3, aluminium chloride / diethyl ether / 22 h / 20 °C
2: sodium hydroxide / methanol; water / 47 h / Reflux
3: AlCl3, aluminium chloride / toluene / 13 h / 70 °C
View Scheme
参考文献
Zhang, Xiaojin; Li, Xiang; Sun, Haopeng; Jiang, Zhengyu; Tao, Lei; Gao, Yuan; Guo, Qinglong; You, Qidong
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 16 p. 3288 - 3299
反应条件
1: 70 percent / PPA
2: 95 percent / H2O, OH- / methanol
3: 90 percent / H2 / 10 percent Pd/C / 760 Torr
View Scheme
参考文献
Khanolkar, Atmaram D.; Lu, Dai; Fan, Pusheng; Tian, Xiaoyu; Makriyannis, Alexandros
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 15 p. 2119 - 2124
反应条件
2: K2CO3 / dimethylformamide
View Scheme
参考文献
Iinuma, Munekazu; Matsuura, Shin; Tanaka, Toshiyuki
Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 4 p. 1472 - 1476
反应条件
1: 9 percent / manganese(III) acetate / acetic acid / 0.02 h / Heating
2: methanol
View Scheme
参考文献
Nishino, Hiroshi; Tsunoda, Katsunori; Kurosawa, Kazu
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 2 p. 545 - 550
