2-(2-溴-4,5-二甲氧基苯基)乙胺盐酸盐合成路线 （共 23 条）
反应条件
in toluene T=20°C; 12 h;
参考文献
Viswanathan, Rajesh; Prabhakaran, Erode N.; Plotkin, Michael A.; Johnston, Jeffrey N.
Journal of the American Chemical Society, 2003 , vol. 125, # 1 p. 163 - 168
反应条件
1: 65 percent / benzene / Heating 2: 23 percent / butyllithium / tetrahydrofuran; hexane / 0.25 h / -100 - -95 °C View Scheme
参考文献
Bradsher, Charles K.; Hunt, David A.
Journal of Organic Chemistry, 1981 , vol. 46, # 2 p. 327 - 330
反应条件
1: benzene / 5 h / Heating 2: 36.2 percent / n-Bu3SnH, AIBN / toluene / Heating 3: 94.8 percent / NaBH4 / methanol; H2O View Scheme
参考文献
Takano, Seiichi; Suzuki, Mahito; Kijima, Atsushi; Ogasawara, Kunio
Chemistry Letters, 1990 , # 2 p. 315 - 316
反应条件
2: lithium aluminum hydride 3: triethylamine 4: stannic chloride / CH2Cl2 / 0 °C 5: 88 percent / Raney Ni / ethanol / Heating 6: 1) POCl3, 2) NaBH4 View Scheme
参考文献
Hanaoka, Miyoji; Hirasawa, Taeko; Cho, Won Jea; Yasuda, Shingo
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 3 p. 399 - 404
反应条件
copper diacetate; palladium diacetate; potassium carbonate in toluene 24 h; Inert atmosphereReflux;
参考文献
Harada, Rika; Nishida, Naoto; Uchiito, Shiho; Onozaki, Yu; Kurono, Nobuhito; Senboku, Hisanori; Masao, Tokuda; Ohkuma, Takeshi; Orito, Kazuhiko
European Journal of Organic Chemistry, 2012 , # 2 p. 366 - 379
反应条件
copper(l) iodide; potassium carbonate; L-proline in dimethyl sulfoxide T=70°C; 45 h; Inert atmosphere;
参考文献
Fan, Kuo-Hsien; Lever, John R.; Lever, Susan Z.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 6 p. 1852 - 1859
反应条件
bromine; acetic acid
T=20°C;
参考文献
Rodriguez, Gema; Castedo, Luis; Dominguez, Domingo; Saa, Carlos; Adam, Waldemar
Journal of Organic Chemistry, 1999 , vol. 64, # 13 p. 4830 - 4833
反应条件
hydrogenchloride in dichloromethane; ethyl acetate
T=20°C; 1 h;
参考文献
MSD OSS B.V.; BLACKABY, Wesley, Peter; DE KORT, Martin; ENTHOVEN, Mark; HINCHLIFFE, Paul, Stuart; PAULIE, Chris; TIMMERS, Cornelis, Marius; VERKAIK, Saskia
Patent: WO2013/41458 A1, 2013 ;
Location in patent: Page/Page column 86 ;
反应条件
bromine in acetic acid
2 h; Ambient temperature;
参考文献
Fidalgo, Jesus; Castedo, Luis; Dominguez, Domingo
Heterocycles, 1994 , vol. 39, # 2 p. 581 - 590
反应条件
ammonia in ethanol; water
T=20°C; 4 h;
参考文献
Kiruthika, Selvarangam E.; Perumal, Paramasivan Thirumalai
Organic Letters, 2014 , vol. 16, # 2 p. 484 - 487
