3-(苄基氨基)丁酸乙酯合成路线 （共 17 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol P=3040 Torr; 3 h;
参考文献
N'Goka; Schlewer; Linget; Chambon; Wermuth
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2547 - 2557
反应条件
1: With NaBH(OAc)3; acetic acid
T=20°C;
2: With sodium carbonate in dichloromethane; water
参考文献
Tummatorn, Jumreang; Dudley, Gregory B.
Organic Letters, 2011 , vol. 13, # 1 p. 158 - 160
反应条件
ytterbium trifluoromethanesulfonate in acetonitrile
T=30°C; P=750.06 Torr; 24 h;
参考文献
Jenner, Gerard
Tetrahedron Letters, 1995 , vol. 36, # 2 p. 233 - 236
反应条件
1: With sodium tris(acetoxy)borohydride; acetic acid in 1,2-dichloro-ethane
T=20°C;
2: With sodium hydrogencarbonate in water; 1,2-dichloro-ethane
参考文献
MITSUBISHI TANABE PHARMA CORPORATION; SANOFI-AVENTIS; WATANABE, Kazutoshi; NAKAYAMA, Kazuki; SAKAI, Daiki
Patent: WO2010/114179 A1, 2010 ;
Location in patent: Page/Page column 30 ;
WO 2010/114179 A1
反应条件
sodium tris(acetoxy)borohydride in acetic acid
2 h; Ambient temperature;
参考文献
Bartoli; Cimarelli; Marcantoni; Palmieri; Petrini
Journal of Organic Chemistry, 1994 , vol. 59, # 18 p. 5328 - 5335
反应条件
ytterbium(III) triflate in tetrahydrofuran
6 h; Ambient temperature;
参考文献
Matsubara, Seijiro; Yoshioka, Masahito; Utimoto, Kiitiro
Chemistry Letters, 1994 , # 5 p. 827 - 830
反应条件
in ethanol
48 h; Heating;
参考文献
N'Goka; Schlewer; Linget; Chambon; Wermuth
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2547 - 2557
反应条件
sodium cyanoborohydride
1.) benzene, reflux, 2.) acetic acid, room temp., 2 h; Yield given. Multistep reaction;
参考文献
Williams; Lee; Miller; Anderson
Journal of the American Chemical Society, 1989 , vol. 111, # 3 p. 1073 - 1081
反应条件
ytterbium trichloride in tetrahydrofuran
17 h; Ambient temperature;
参考文献
Matsubara, Seijiro; Yoshioka, Masahito; Utimoto, Kiitiro
Chemistry Letters, 1994 , # 5 p. 827 - 830
反应条件
1: zirconium tetrachloride / 20 °C / Neat (no solvent)
2: NaBH(OAc)3; acetic acid / 20 °C
View Scheme
参考文献
Tummatorn, Jumreang; Dudley, Gregory B.
Organic Letters, 2011 , vol. 13, # 1 p. 158 - 160
