(2Z)-2-羟基亚胺-N-(4-甲氧基苯基)乙酰胺合成路线 （共 10 条）
反应条件
1: water; sulfuric acid 2: pyridine; hydroxylamine hydrochloride View Scheme
参考文献
Bartlett et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 126,135
反应条件
1: water; sulfuric acid 2: triethylamine; dioxane / anschliessend mit wss. HCl behandeln 3: palladium/charcoal; acetic acid / Hydrogenation 4: quinoline 5: sodium; isobutyl alcohol View Scheme
参考文献
Farmaco, Edizione Scientifica, , vol. 13, p. 75,78
反应条件
sulfuric acid; water T=65 - 80°C;
参考文献
Lozinskaya, Natalia A.; Sosonyuk, Sergey E.; Volkova, Maria S.; Seliverstov, Michael Yu.; Proskurnina, Marina V.; Bachurin, Sergey E.; Zefirov, Nikolay S.
Synthesis, 2011 , # 2 art. no. Z18110SS, p. 273 - 276
反应条件
1: sulfuric acid / Behandeln des erhaltenen 5-Methoxy-isatins mit wss. Natronlauge und wss. Wasserstoffperoxid View Scheme
参考文献
Journal of the American Chemical Society, , vol. 68, p. 1599,1601
反应条件
sulfuric acid Behandeln des erhaltenen 5-Methoxy-isatins mit wss. Natronlauge und wss. Wasserstoffperoxid;
参考文献
Bachman; Picha
Journal of the American Chemical Society, 1946 , vol. 68, p. 1599,1601
反应条件
1: water; sulfuric acid 2: pyridine; hydroxylamine hydrochloride 3: PCl5 4: aqueous NaOH View Scheme
参考文献
Bartlett et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 126,135
反应条件
hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate in water
0.166667 h; Reflux;
参考文献
FUJIFILM Corporation
Patent: EP1049117 B1, 2011 ;
Location in patent: Page/Page column 37-39 ;
反应条件
1: chloral With hydroxylamine hydrochloride; sodium sulfate in water
T=60°C;
2: 4-methoxy-aniline With hydrogenchloride in water
T=80°C;
参考文献
Sugen, Inc.
Patent: US6350754 B2, 2002 ;
Location in patent: Page column 25 ;
反应条件
hydroxylamine hydrochloride; water; sodium sulfate
参考文献
Bachman; Picha
Journal of the American Chemical Society, 1946 , vol. 68, p. 1599,1601
反应条件
1: 67.7 percent / 90percent H2SO4 / 0.5 h / 70 °C
2: 1) 30percent H2O2, 5percent aq. NaOH; 2) conc. HCl
3: 50 percent / POCl3 / 1 h / Heating
4: 1) 47percent HBr, 2) 10percent KOH / 1) reflux, 5 h
View Scheme
参考文献
Karimov, A.; Telezhenetskaya, M. V.; Yunusov, S. Yu.
Chemistry of Natural Compounds, 1982 , vol. 18, # 4 p. 466 - 472
Khimiya Prirodnykh Soedinenii, 1982 , vol. 18, # 4 p. 498 - 504
