4-甲氧基苄基丙二酸二乙酯合成路线 （共 17 条）
参考文献
Kumar, Satish; Kapoor, Kamal K.
Synlett, 2007 , # 18 p. 2809 - 2814
反应条件
2.) 175 deg C, 10 Torr pressure; Multistep reaction;
参考文献
Fletcher, David; Ablenas, Fred J.; Hopkinson, Alan C.; Lee-Ruff, Edward
Tetrahedron Letters, 1986 , vol. 27, # 40 p. 4853 - 4856
参考文献
Darzens; Levy
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1935 , vol. 200, p. 469
反应条件
1: 95 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating
2: 96 percent / 2,6-di-tert-butyl-p-cresole, Lipase PS / diisopropyl ether; H2O / 1.5 h / Ambient temperature
3: 91 percent / 4-dimethylaminopyridine, pyridine / CH2Cl2 / 15 h / Ambient temperature
4: 93 percent / guanidine / ethanol / 1 h / Ambient temperature
5: 99 percent / pyridine / CH2Cl2 / 40 h / Ambient temperature
6: 88 percent / dimethylsulfoxide / 24 h / 90 °C
7: 1.) aq. 2M-NaOH; 2.) aq. 2M-NaOH / 1.) ETOH, r.t., 18 h; 2.) 3h reflux
View Scheme
参考文献
Shiotani, Shunsaku; Okada, Hirohiko; Yaroamoto, Takako; Nakamata, Kumiko; Adachi, Jun; Nakamoto, Hiromasa
Heterocycles, 1996 , vol. 43, # 1 p. 113 - 126
参考文献
Buckle et al.
Journal of the Chemical Society, 1954 , p. 3981,3984
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
4 h; Heating;
参考文献
Shiotani, Shunsaku; Okada, Hirohiko; Yaroamoto, Takako; Nakamata, Kumiko; Adachi, Jun; Nakamoto, Hiromasa
Heterocycles, 1996 , vol. 43, # 1 p. 113 - 126
反应条件
1: (i) NBS, (ii) /BRN= 889863/, NaOEt
2: liq. HF
3: KOH
View Scheme
参考文献
Kandeel; Anderson; Block; White; Martin
Journal of pharmaceutical sciences, 1972 , vol. 61, # 8 p. 1231 - 1234
