4-甲氧基苄基丙二酸二乙酯合成路线 （共 17 条）
反应条件
1: methanol. NH3; methanol. sodium methylate 2: P2O5 / 20 Torr View Scheme
参考文献
Russell; Hitchings
Journal of the American Chemical Society, 1952 , vol. 74, p. 3443
反应条件
1: 2-(4-methoxybenzyl)malonic acid diethyl ester With potassium hydride in acetonitrile T=20°C; 0.333333 h; Inert atmosphereGlovebox; 2: 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium in acetonitrile T=24.84°C; Inert atmosphereGlovebox; Thermodynamic data;
参考文献
Cao, Ying; Zhang, Song-Chen; Zhang, Min; Shen, Guang-Bin; Zhu, Xiao-Qing
Journal of Organic Chemistry, 2013 , vol. 78, # 14 p. 7154 - 7168
反应条件
1: ethanolic KOH View Scheme
参考文献
Cordier; Vedrine
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1953 , vol. 236, p. 1042
反应条件
1,4-diaza-bicyclo[2.2.2]octane; tris(pentafluorophenyl)-borane; hydrogen in toluene
T=80°C; P=45004.5 Torr; 24 h; AutoclaveInert atmosphere;
参考文献
Ines, Blanca; Palomas, David; Holle, Sigrid; Steinberg, Sebastian; Nicasio, Juan A.; Alcarazo, Manuel
Angewandte Chemie - International Edition, 2012 , vol. 51, # 49 p. 12367 - 12369
Angew. Chem., 2012 , vol. 124, # 49 p. 12533 - 12536,4
反应条件
1: 2,3-dihydro-2-(4-methoxyphenyl)-1H-benzoimidazole / Heating
View Scheme
参考文献
Kumar, Satish; Kapoor, Kamal K.
Synlett, 2007 , # 18 p. 2809 - 2814
反应条件
sodium ethanolate in ethanol
T=20°C; Alkylation; 24 h;
参考文献
Atlan; Kaim, L. El; Lacroix; Morgentin
Chemical Communications, 1999 , # 18 p. 1893 - 1894
反应条件
1: 2,3-dihydro-2-(4-methoxyphenyl)-1H-benzoimidazole / Heating
View Scheme
参考文献
Kumar, Satish; Kapoor, Kamal K.
Synlett, 2007 , # 18 p. 2809 - 2814
反应条件
hydrogen; ethylenediamine diacetic acid; 1-n-butyl-3-methylimidazolium tetrafluoroborate; palladium on activated charcoal
T=90°C; Knoevenagel condensation; P=2250.18 Torr; 17 h;
参考文献
Baidossi, Mubeen; Joshi, Asutosh V.; Mukhopadhyay, Sudip; Sasson, Yoel
Tetrahedron Letters, 2005 , vol. 46, # 11 p. 1885 - 1887
反应条件
1: diethyl malonate With sodium ethanolate in ethanol
T=20°C;
2: 1-bromomethyl-4-methoxy-benzene in ethanol
Reflux;
参考文献
Yip, Kai-Tai; Yang, Dan
Organic Letters, 2011 , vol. 13, # 8 p. 2134 - 2137
反应条件
sodium hydride
1.) mineral oil, THF, r.t., 30 min; 2.) THF, 4 h, reflux;
参考文献
Shiotani, Shunsaku; Okada, Hirohiko; Yaroamoto, Takako; Nakamata, Kumiko; Adachi, Jun; Nakamoto, Hiromasa
Heterocycles, 1996 , vol. 43, # 1 p. 113 - 126
