5-甲氧基-6-甲基-3,4-吡啶二甲醇合成路线 （共 12 条）
反应条件
1: water; hydrobromic acid 2: water View Scheme
参考文献
Kuhn; Wendt
Chemische Berichte, 1939 , vol. 72, p. 311
反应条件
methanol; diethyl ether
参考文献
Stitter et al.
Journal of the American Chemical Society, 1939 , vol. 61, p. 1237,1241
反应条件
lithium metaborate; diethyl ether
参考文献
E.Lilly and Co.
Patent: US2744114 , 1952 ;
反应条件
1: urea; acetic acid anhydride; HNO3
2: POCl3; PCl5 / 120 - 130 °C
3: palladium/BaCO3; ethanol / 36775.4 - 44130.5 Torr / Hydrogenation
4: concentrated aqueous HCl
5: aqueous H2SO4; aqueous NaNO2 / 90 - 95 °C
6: diethyl ether; methanol / -15 °C
7: lithium alanate; diethyl ether / 0 °C
View Scheme
参考文献
Wuest et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 226,240
反应条件
1: palladium/BaCO3; ethanol / 36775.4 - 44130.5 Torr / Hydrogenation
2: concentrated aqueous HCl
3: aqueous H2SO4; aqueous NaNO2 / 90 - 95 °C
4: diethyl ether; methanol / -15 °C
5: lithium alanate; diethyl ether / 0 °C
View Scheme
参考文献
Wuest et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 226,240
反应条件
1: POCl3; PCl5 / 120 - 130 °C
2: palladium/BaCO3; ethanol / 36775.4 - 44130.5 Torr / Hydrogenation
3: concentrated aqueous HCl
4: aqueous H2SO4; aqueous NaNO2 / 90 - 95 °C
5: diethyl ether; methanol / -15 °C
6: lithium alanate; diethyl ether / 0 °C
View Scheme
参考文献
Wuest et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 226,240
反应条件
1: diethylamine; ethanol
2: urea; acetic acid anhydride; HNO3
3: POCl3; PCl5 / 120 - 130 °C
4: palladium/BaCO3; ethanol / 36775.4 - 44130.5 Torr / Hydrogenation
5: concentrated aqueous HCl
6: aqueous H2SO4; aqueous NaNO2 / 90 - 95 °C
7: diethyl ether; methanol / -15 °C
8: lithium alanate; diethyl ether / 0 °C
View Scheme
参考文献
Wuest et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 226,240
反应条件
1: concentrated aqueous HCl
2: aqueous H2SO4; aqueous NaNO2 / 90 - 95 °C
3: diethyl ether; methanol / -15 °C
4: lithium alanate; diethyl ether / 0 °C
View Scheme
参考文献
Wuest et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 226,240
反应条件
1: aqueous H2SO4; aqueous NaNO2 / 90 - 95 °C
2: diethyl ether; methanol / -15 °C
3: lithium alanate; diethyl ether / 0 °C
View Scheme
参考文献
Wuest et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 226,240
反应条件
1: diethyl ether; methanol / -15 °C
2: lithium alanate; diethyl ether / 0 °C
View Scheme
参考文献
Wuest et al.
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 226,240
