2-氨基-5-氯-3-硝基苯甲酸合成路线 （共 17 条）
反应条件
1: 1.8 g / stannous chloride dihydrate / HCl / 100 °C 2: 1.6 g / H2, KOH / Raney nickel / ethanol 3: 2.) sodium carbonate, deactivated Raney Ni / 1.) acetic acid, water (1:1), 15 min, warming; 2.) water, 70 deg C, 3 h View Scheme
参考文献
Deady, Leslie W.; Kaye, Anthony J.
Australian Journal of Chemistry, 1997 , vol. 50, # 5 p. 473 - 478
反应条件
1: With water; lithium hydroxide hydrate
1 h; Reflux;
2: With hydrogenchloride in water
T=20°C; pH=2;
参考文献
BAYER CROPSCIENCE AG
Patent: US2011/218103 A1, 2011 ;
Location in patent: Page/Page column 13 ;
反应条件
sodium hydroxide in water
3 h; Heating;
参考文献
Zhou, Zhang-Lin; Kher, Sunil M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1769 - 1780
反应条件
sodium hypochlorite; potassium hydroxide
参考文献
Barkalow, Jufang H.; Breting, Jeffrey; Gaede, Bruce J.; Haight, Anthony R.; Henry, Rodger; Kotecki, Brian; Mei, Jianzhang; Pearl, Kurt B.; Tedrow, Jason S.; Viswanath, Shekhar K.
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 693 - 698
参考文献
GAF Corporation
Patent: US3931303 A1, 1976 ;
反应条件
sulfuric acid; sodium nitrite
参考文献
Adams; Snyder
Journal of the American Chemical Society, 1938 , vol. 60, p. 1411,1413
参考文献
Tsuda; Oguri
Yakugaku Zasshi, 1942 , vol. 62, p. 66,68; dtsch. Ref. S. 24
Chem.Abstr., 1951 , p. 1580
Full Text Show Details
Magidson; Golowtschinskaja
Zhurnal Obshchei Khimii, 1938 , vol. 8, p. 1797,1801
Chem. Zentralbl., 1940 , vol. 111, # I p. 370
反应条件
1: 67 percent / dioxane / 12 h / 20 °C
2: 82 percent / conc. H2SO4; KNO3 / 24 h / 20 °C
3: 82 percent / NaOH / H2O / 3 h / Heating
View Scheme
参考文献
Zhou, Zhang-Lin; Kher, Sunil M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F. W.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1769 - 1780
反应条件
1.1: acetic anhydride / isopropanol acetate / 60 °C / |Inert atmosphere; |Large scale
2.1: ammonium hydroxide / 2.5 h / 0 - 15 °C / |Inert atmosphere; |Large scale
2.2: 20 °C / |Inert atmosphere; |Large scale
3.1: potassium hydroxide; bromine / water / 1.5 h / 0 - 75 °C / |Inert atmosphere; |Large scale
4.1: potassium hydroxide; sodium hypochlorite
View Scheme
参考文献
Barkalow, Jufang H.; Breting, Jeffrey; Gaede, Bruce J.; Haight, Anthony R.; Henry, Rodger; Kotecki, Brian; Mei, Jianzhang; Pearl, Kurt B.; Tedrow, Jason S.; Viswanath, Shekhar K.
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 693 - 698
反应条件
1.1: ammonium hydroxide / 2.5 h / 0 - 15 °C / |Inert atmosphere; |Large scale
1.2: 20 °C / |Inert atmosphere; |Large scale
2.1: potassium hydroxide; bromine / water / 1.5 h / 0 - 75 °C / |Inert atmosphere; |Large scale
3.1: potassium hydroxide; sodium hypochlorite
View Scheme
参考文献
Barkalow, Jufang H.; Breting, Jeffrey; Gaede, Bruce J.; Haight, Anthony R.; Henry, Rodger; Kotecki, Brian; Mei, Jianzhang; Pearl, Kurt B.; Tedrow, Jason S.; Viswanath, Shekhar K.
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 693 - 698
