5-(4-氯苄基)-2-硫氧代-2,3-二氢嘧啶-4(1h)-酮合成路线 （共 8 条）
反应条件
1: HCl / diethyl ether / Heating
2: H2 / PtO2 / ethanol
3: 1.) Na, 3.) conc. HCl
View Scheme
参考文献
Orr; Musso; Boswell; Kelley; Joyner; Davis; Baccanari
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3850 - 3856
反应条件
1: H2 / PtO2 / ethanol
2: 1.) Na, 3.) conc. HCl
View Scheme
参考文献
Orr; Musso; Boswell; Kelley; Joyner; Davis; Baccanari
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3850 - 3856
反应条件
1: hydrogen / 5percent Pd/C / ethanol
2: sodium wire / diethyl ether / 18 h / Ambient temperature
3: ethanol / 7 h / Heating
View Scheme
参考文献
Brown; Blakemore; Durant; Emmett; Ganellin; Parsons; Rawlings; Walker
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 1 p. 53 - 62
反应条件
1: 1) piperidine, 2) conc. H2SO4 / 1) pyridine
2: hydrogen / 5percent Pd/C / ethanol
3: sodium wire / diethyl ether / 18 h / Ambient temperature
4: ethanol / 7 h / Heating
View Scheme
参考文献
Brown; Blakemore; Durant; Emmett; Ganellin; Parsons; Rawlings; Walker
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 1 p. 53 - 62
参考文献
Falco et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 4466
反应条件
1: sodium wire / diethyl ether / 18 h / Ambient temperature
2: ethanol / 7 h / Heating
View Scheme
参考文献
Brown; Blakemore; Durant; Emmett; Ganellin; Parsons; Rawlings; Walker
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 1 p. 53 - 62
反应条件
hydrogenchloride; sodium
Multistep reaction;
参考文献
Orr; Musso; Boswell; Kelley; Joyner; Davis; Baccanari
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3850 - 3856
反应条件
in ethanol
7 h; Heating; Yield given;
参考文献
Brown; Blakemore; Durant; Emmett; Ganellin; Parsons; Rawlings; Walker
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 1 p. 53 - 62
