5-(2-噻吩基亚甲基)-2-硫酮噻唑烷-4-酮合成路线 （共 11 条）
反应条件
1: aq. NaOH solution 2: ethanol; hydroxylamine 3: acetic acid anhydride 4: aqueous hydrogen peroxide; aqueous KOH-solution View Scheme
参考文献
Crowe; Nord
Journal of Organic Chemistry, 1950 , vol. 15, p. 81,87
反应条件
sodium hydroxide T=45 - 60°C; 0.5 h;
参考文献
Kukolja; Draheim; Graves; Hunden; Pfeil; Cooper; Ott; Counter
Journal of medicinal chemistry, 1985 , vol. 28, # 12 p. 1896 - 1903
反应条件
1: 93 g / 8 percent NaOH / 0.5 h / 45 - 60 °C 2: Cl2 / 1,1,2-trichloro-ethane / 1.) RT, 1 h, 2.) reflux, 1 h 3: 400 g / HCl / 2 h / Heating View Scheme
参考文献
Kukolja; Draheim; Graves; Hunden; Pfeil; Cooper; Ott; Counter
Journal of medicinal chemistry, 1985 , vol. 28, # 12 p. 1896 - 1903
反应条件
1: aq. NaOH solution 2: ethanol; hydroxylamine 3: acetic acid anhydride 4: aq.-ethanolic KOH-solution View Scheme
参考文献
Crowe; Nord
Journal of Organic Chemistry, 1950 , vol. 15, p. 81,87
反应条件
1: aq. NaOH solution 2: ethanol; hydroxylamine 3: acetic acid anhydride View Scheme
参考文献
Journal of Organic Chemistry, , vol. 15, p. 81,87
反应条件
1: aq. NaOH solution 2: ethanol; hydroxylamine 3: ethanol; sodium-amalgam View Scheme
参考文献
Journal of Organic Chemistry, , vol. 15, p. 81,87
反应条件
1: aq. NaOH solution 2: ethanol; hydroxylamine 3: acetic acid anhydride 4: lithium alanate; diethyl ether View Scheme
参考文献
Crowe; Nord
Journal of Organic Chemistry, 1950 , vol. 15, p. 81,87
反应条件
1: 93 g / 8 percent NaOH / 0.5 h / 45 - 60 °C 2: Cl2 / 1,1,2-trichloro-ethane / 1.) RT, 1 h, 2.) reflux, 1 h View Scheme
参考文献
Kukolja; Draheim; Graves; Hunden; Pfeil; Cooper; Ott; Counter
Journal of medicinal chemistry, 1985 , vol. 28, # 12 p. 1896 - 1903
反应条件
thiourea; urea
T=110°C; Knoevenagel condensation; 0.133333 h; Neat (no solvent);
参考文献
Shah, Sakshi; Singh, Baldev
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 17 p. 5388 - 5391
反应条件
sodium hydroxide in tetrahydrofuran; acetone
Ambient temperature;
参考文献
Foye; Tovivich
Journal of Pharmaceutical Sciences, 1977 , vol. 66, # 11 p. 1607 - 1611
