5-硝基噻吩-2-甲酸合成路线

参考文献

Cogolli, Pietro; Maiolo, Filippo; Testaferri, Lorenzo; Tiecco, Marcello; Tingoli, Marco
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1980 , p. 1331 - 1335

7647-01-0盐酸+

67-56-1甲醇+

6317-37-95-硝基噻吩-2-甲酸

5832-01-95-硝基-噻吩-2-甲酸甲酯

参考文献

Imoto et al.
Nippon Kagaku Zasshi, 1956 , vol. 77, p. 804,807
Chem.Abstr., 1958 , p. 9066

6317-37-95-硝基噻吩-2-甲酸

14597-58-15-氨基噻吩-2-甲酸甲酯

参考文献

Skerlj, Renato T.; Bastos, Cecilia M.; Booker, Michael L.; Kramer, Martin L.; Barker, Robert H.; Celatka, Cassandra A.; O'Shea, Thomas J.; Munoz, Benito; Sidhu, Amar Bir; Cortese, Joseph F.; Wittlin, Sergio; Papastogiannidis, Petros; Angulo-Barturen, Inigo; Jimenez-Diaz, Maria Belen; Sybertz, Edmund
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 9 p. 708 - 713

6317-37-95-硝基噻吩-2-甲酸+

108-93-0环己醇

891845-32-2

参考文献

GLAXO GROUP LIMITED
Patent: WO2006/65755 A2, 2006 ;
Location in patent: Page/Page column 15 ;

6317-37-95-硝基噻吩-2-甲酸+

108-24-7乙酸酐

89499-46-75-(乙酰氨基)噻吩-2-羧酸

参考文献

Glushkova, A. A.; Morgunova, L. M.; Freidlin, G. N.; Fedorov, A. Ya.; Ivanov, V. F.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 4 p. 380 - 384
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 4 p. 455 - 459

6317-37-95-硝基噻吩-2-甲酸+

64-17-5乙醇

5751-84-85-硝基-2-噻吩甲酸乙酯

参考文献

Aventis Pharma S.A.
Patent: US2005/154048 A1, 2005 ;
Location in patent: Page/Page column 20 ;

5751-84-85-硝基-2-噻吩甲酸乙酯

参考文献

Dann
Chemische Berichte, 1943 , vol. 76, p. 419,428

6317-37-95-硝基噻吩-2-甲酸

5832-00-8

参考文献

MERCK and CO., INC.
Patent: WO2008/156726 A1, 2008 ;
Location in patent: Page/Page column 102 ;
WO 2008/156726 A1