4-(苯乙炔基)苯甲酸乙酯合成路线 （共 17 条）
反应条件
diisopropylammonium bromide; [(t-Bu)3PH]BF4; copper(l) iodide; Na2[PdCl4] in various solvent(s) T=80°C; Sonogashira coupling; 7 h;
参考文献
Advanced Synthesis and Catalysis, , vol. 347, # 9 p. 1295 - 1300
反应条件
tetrakis(triphenylphosphine) palladium(0); copper(l) chloride in N,N-dimethyl-formamide T=80°C; sila-Sonogashira reaction; 1 h;
参考文献
Tetrahedron Letters, , vol. 50, # 32 p. 4643 - 4646
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diisopropylamine T=0°C; Sonogashira Cross-Coupling; Inert atmosphere; Reagent/catalystTemperature;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 5 p. 1527 - 1530
Angew. Chem., , vol. 125, # 5 p. 1567 - 1570,4
反应条件
1: 3-phenyl-2-propynoic acid With silver(l) oxide in N,N-dimethyl-formamide T=20°C; 0.0833333 h; Inert atmosphere; 2: 4-iodobenzoic acid ethyl ester With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; triphenylphosphine; lithium iodide in N,N-dimethyl-formamide T=100°C; Sonogashira coupling; 1 h; Inert atmosphere;
参考文献
Advanced Synthesis and Catalysis, , vol. 351, # 17 p. 2827 - 2832
反应条件
tetrabutylammomium bromide; palladium diacetate in tetrahydrofuran T=60°C; Negishi coupling; Inert atmosphere;
参考文献
Organic Letters, , vol. 10, # 13 p. 2661 - 2664
反应条件
1: With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; lithium chloride; silver(l) oxide in N,N-dimethyl-formamide T=70°C; 2 h; Inert atmosphere; 2: Sonogashira coupling;
参考文献
Advanced Synthesis and Catalysis, , vol. 351, # 17 p. 2827 - 2832
反应条件
copper(l) chloride; palladium dichloride; tris(p-fluoro phenyl)phosphine in N,N-dimethyl-formamide T=100°C; sila-Sonogashira-Hagihara cross-coupling; 12 h; Inert atmosphere;
参考文献
Tetrahedron, , vol. 68, # 24 p. 4869 - 4881
反应条件
triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride T=90°C; P=15200 Torr; 8 h;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 7 p. 333 - 334
反应条件
complex of lt;PdCl(π-C3H5)gt;2 and N-(2-diphenylphosphinobenzylidene)-2-phenylethylamine in tetrahydrofuran T=50°C; 18 h;
参考文献
Tetrahedron Letters, , vol. 38, # 21 p. 3759 - 3762
反应条件
bis-triphenylphosphine-palladium(II) chloride; oxygen in 1,4-dioxane T=80°C; Sonogashira type coupling; 18 h;
参考文献
Tetrahedron Letters, , vol. 50, # 46 p. 6293 - 6297
