2-甲氧基-5-甲基苯甲酸甲酯合成路线 （共 24 条）
反应条件
hydrogenchloride in water
Reflux;
参考文献
Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420
反应条件
in diethyl ether
Yield given;
参考文献
Schlosser, Manfred; Maccaroni, Paola; Marzi, Elena
Tetrahedron, 1998 , vol. 54, # 12 p. 2763 - 2770
反应条件
1: thionyl chloride
View Scheme
参考文献
Anschuetz
Justus Liebigs Annalen der Chemie, 1925 , vol. 442, p. 41
参考文献
Guillaumin
Bulletin de la Societe Chimique de France, 1910 , vol. <4> 7, p. 334
参考文献
Anschuetz
Justus Liebigs Annalen der Chemie, 1925 , vol. 442, p. 41
反应条件
1: 87 percent / LiAlH4 / tetrahydrofuran / 20 h / Heating
2: 69 percent / thionyl chloride, pyridine / toluene / 24 h / Ambient temperature
View Scheme
参考文献
Langlois, Michel; Bremont, Beatrice; Shen, Shuren; Poncet, Annie; Andrieux, Jean; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2050 - 2060
反应条件
1: 87 percent / LiAlH4 / tetrahydrofuran / 20 h / Heating
2: 69 percent / thionyl chloride, pyridine / toluene / 24 h / Ambient temperature
3: 91 percent / KI / dimethylsulfoxide / 20 h / Ambient temperature
View Scheme
参考文献
Langlois, Michel; Bremont, Beatrice; Shen, Shuren; Poncet, Annie; Andrieux, Jean; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2050 - 2060
反应条件
n-butyllithium in diethyl ether; hexane
0.5 h; Heating;
参考文献
Gunzenhauser, Sigmund; Balli, Heinz
Helvetica Chimica Acta, 1985 , vol. 68, p. 56 - 63
反应条件
1: 66 percent / 1.) BuLi / hexane; diethyl ether / 0.5 h / Heating
2: 62 percent / O-(Mesitylsulfonyl)hydroxylamin / CH2Cl2 / 15 h / Ambient temperature
View Scheme
参考文献
Gunzenhauser, Sigmund; Balli, Heinz
Helvetica Chimica Acta, 1985 , vol. 68, p. 56 - 63
反应条件
1: 66 percent / 1.) BuLi / hexane; diethyl ether / 0.5 h / Heating
2: 62 percent / O-(Mesitylsulfonyl)hydroxylamin / CH2Cl2 / 15 h / Ambient temperature
3: 86 percent / 1.) Me3SiI, H2O / 6 h / 100 °C
View Scheme
参考文献
Gunzenhauser, Sigmund; Balli, Heinz
Helvetica Chimica Acta, 1985 , vol. 68, p. 56 - 63
