2-甲氧基-5-甲基苯甲酸甲酯合成路线 （共 24 条）
反应条件
1: diethyl ether 2: acetic acid anhydride 3: sodium; absolute alcohol / durch Verseifen mit Bromwasserstoffsaeure in Eisessig 4: NaOH-solution View Scheme
参考文献
Guillaumin
Bulletin de la Societe Chimique de France, 1910 , vol. <4> 7, p. 334
反应条件
1: diethyl ether 2: acetic acid anhydride 3: sodium; absolute alcohol / durch Verseifen mit Bromwasserstoffsaeure in Eisessig View Scheme
参考文献
Guillaumin
Bulletin de la Societe Chimique de France, 1910 , vol. <4> 7, p. 334
反应条件
1: KOH / methanol; H2O / 2 h / Heating 2: SOCl2 / 16 h / Heating View Scheme
参考文献
Paul, Tapas; Malachowski, William P.; Lee, Jisun
Organic Letters, 2006 , vol. 8, # 18 p. 4007 - 4010
参考文献
Paul, Tapas; Malachowski, William P.; Lee, Jisun
Organic Letters, 2006 , vol. 8, # 18 p. 4007 - 4010
反应条件
1: 87 percent / lithium aluminium hydride / diethyl ether / 1 h / 0 °C 2: 77 percent / pyridinium chlorochromate / CH2Cl2 / 1 h / Ambient temperature View Scheme
参考文献
Nagamatsu, Tomohisa; Kuroda, Kazunori; Mimura, Norio; Yanada, Reiko; Yoneda, Fumio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 9 p. 1125 - 1128
反应条件
1: diethyl ether 2: acetic acid anhydride 3: absolute alcohol; sodium View Scheme
参考文献
Guillaumin
Bulletin de la Societe Chimique de France, 1910 , vol. <4> 7, p. 334
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=0 - 20°C; 12 h;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1550662 A1, 2005 ;
Location in patent: Page/Page column 28 ;
反应条件
potassium carbonate in acetone
6 h; Heating;
参考文献
Langlois, Michel; Bremont, Beatrice; Shen, Shuren; Poncet, Annie; Andrieux, Jean; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2050 - 2060
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
Yeung, Kap-Sun; Meanwell, Nicholas A.; Qiu, Zhilei; Hernandez, Dennis; Zhang, Sharon; McPhee, Fiona; Weinheimer, Steve; Clark, James M.; Janc, James W.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 17 p. 2355 - 2359
反应条件
1: 1.) lithium 2,2,6,6-tetramethylpiperidide, tBuOK / 1.) THF, -50 deg C, 3 h.
2: diethyl ether
View Scheme
参考文献
Schlosser, Manfred; Maccaroni, Paola; Marzi, Elena
Tetrahedron, 1998 , vol. 54, # 12 p. 2763 - 2770
