2-氯-5-硝基苯甲酸甲酯合成路线 （共 20 条）
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 19, p. 55
反应条件
hydrogen in ethyl acetate T=50°C; P=7600.51 Torr; 4 h; chemoselective reaction;
参考文献
Takasaki, Mikihiro; Motoyama, Yukihiro; Higashi, Kenji; Yoon, Seong-Ho; Mochida, Isao; Nagashima, Hideo
Organic Letters, 2008 , vol. 10, # 8 p. 1601 - 1604
反应条件
hydrogenchloride in ethanol; dichloromethane; water; ethyl acetate
参考文献
Rhone-Poulenc Rorer S.A.
Patent: US5382590 A1, 1995 ;
反应条件
potassium fluoride; PEG 5090 in dimethyl sulfoxide T=115°C; 12 h;
参考文献
Deutsch; Niclas
Synthetic Communications, 1991 , vol. 21, # 4 p. 505 - 513
反应条件
1: 56 percent / 3 h / Heating 2: 86 percent / H2, HCl / Pd-C / methanol View Scheme
参考文献
Kosary; Szabo; Kasztreiner
Pharmazie, 1982 , vol. 37, # 7 p. 484 - 486
反应条件
2: H2 / Raney-Ni 3: aq. HCl View Scheme
参考文献
Popoff; Engle; Whitaker; Singhal
Journal of medicinal chemistry, 1971 , vol. 14, # 12 p. 1166 - 1169
反应条件
triethylamine in methanol
T=40 - 50°C; 4 h;
参考文献
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; WIPF, Peter; WANG, Qiming, Jan
Patent: WO2012/78859 A2, 2012 ;
Location in patent: Page/Page column 55 ;
反应条件
potassium carbonate in dimethyl sulfoxide
T=60°C; 4 h;
参考文献
Japan Tobacco Inc.
Patent: EP1688420 A1, 2006 ;
Location in patent: Page/Page column 119 ;
参考文献
Kosary; Szabo; Kasztreiner
Pharmazie, 1982 , vol. 37, # 7 p. 484 - 486
参考文献
Nagarajan,K. et al.
Indian Journal of Chemistry, 1974 , vol. 12, p. 236 - 246
