(3-溴苯基)(苯基)甲醇合成路线 （共 5 条）
反应条件
AlCl3, aluminium chloride; lithium aluminium tetrahydride in diethyl ether T=-20°C; Inert atmosphereReflux;
参考文献
Peters, Martin; Trobe, Melanie; Tan, Hao; Kleineweischede, Rolf; Breinbauer, Rolf
Chemistry - A European Journal, 2013 , vol. 19, # 7 p. 2442 - 2449
反应条件
pyridinium chlorochromate in dichloromethane T=20°C; 4.5 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 16 p. 4405 - 4409
反应条件
anhydrous potassium sulfate; dipotassium hydrogenphosphate; Nocardia corallina B-276 in octane; N,N-dimethyl-formamide T=28 - 30°C; 8 h;
参考文献
Tetrahedron Asymmetry, , vol. 11, # 21 p. 4263 - 4268
反应条件
1.1: triethylsilane; boron trifluoride etherate / CH2Cl2 / 20 °C
2.1: n-butyl lithium / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
参考文献
Wai; Egbertson; Payne; Fisher; Embrey; Tran; Melamed; Langford; Guare J.P.; Zhuang; Grey; Vacca; Holloway; Naylor-Olsen; Hazuda; Felock; Wolfe; Stillmock; Schleif; Gabryelski; Young
Journal of Medicinal Chemistry, 2000 , vol. 43, # 26 p. 4923 - 4926
反应条件
1: 83 percent / AlCl3, LiAlH4 / diethyl ether / 1.5 h / Heating
2: 1.) Mg / 1.) THF, 1,2-dibromoethane, reflux, 2.5 h, 2.) THF, 1,2-dibromoethane, RT, overnight
View Scheme
参考文献
Matsuda, Kenji; Nakamura, Nobuo; Takahashi, Kazuyuki; Inoue, Katsuya; Koga, Noboru; Iwamura, Hiizu
Journal of the American Chemical Society, 1995 , vol. 117, # 20 p. 5550 - 5560
