3-(4-苯基苯基)环己-2-烯-1-酮合成路线 （共 10 条）
反应条件
(i) nBuLi, (ii) /BRN= 3306138/, (iii) Pd-C, (heating); Multistep reaction;
参考文献
Doss,R.C.; Solomon,P.W.
Journal of Organic Chemistry, 1964 , vol. 29, p. 1567 - 1574
反应条件
1: cyclohexenon; p-iodophenyl boronic acid With 2,9-dimethyl-1,10-phenanthroline; oxygen; palladium diacetate in N,N-dimethyl-formamide
T=20°C; Boron-Heck reaction; 16 h;
2: 3,4,5-trimethoxyphenylboronic acid With sodium hydroxide in N,N-dimethyl-formamide
T=90°C; Suzuki coupling; 6 h; Inert atmosphere;
参考文献
O'Neill, Justin; Yoo, Kyung Soo; Jung, Kyung Woon
Tetrahedron Letters, 2008 , vol. 49, # 51 p. 7307 - 7310
反应条件
1: cyclohexenon; para-bromophenylboronic acid With 2,9-dimethyl-1,10-phenanthroline; oxygen; palladium diacetate in N,N-dimethyl-formamide
T=20°C; Boron-Heck reaction; 16 h;
2: 3,4,5-trimethoxyphenylboronic acid With sodium hydroxide in N,N-dimethyl-formamide
T=90°C; Suzuki coupling; 6 h; Inert atmosphere;
参考文献
O'Neill, Justin; Yoo, Kyung Soo; Jung, Kyung Woon
Tetrahedron Letters, 2008 , vol. 49, # 51 p. 7307 - 7310
反应条件
[Pd(CH3CN)4](BF4)2; 6,6'-dimethyl-2,2'-bipyridine; anthraquinone-2-sulfonic acid sodium salt; oxygen in 1-methyl-pyrrolidin-2-one
T=50°C; Heck Reaction; P=760.051 Torr; 13 h;
参考文献
Izawa, Yusuke; Zheng, Changwu; Stahl, Shannon S.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 13 p. 3672 - 3675
Angew. Chem., 2013 , vol. 125, # 13 p. 3760 - 3763,4
反应条件
1: cyclohexenon; (4-Chlorophenyl)-boronic acid With 2,9-dimethyl-1,10-phenanthroline; oxygen; palladium diacetate in N,N-dimethyl-formamide
T=20°C; Boron-Heck reaction; 16 h;
2: 3,4,5-trimethoxyphenylboronic acid With sodium hydroxide in N,N-dimethyl-formamide
T=90°C; Suzuki coupling; 6 h; Inert atmosphere;
参考文献
O'Neill, Justin; Yoo, Kyung Soo; Jung, Kyung Woon
Tetrahedron Letters, 2008 , vol. 49, # 51 p. 7307 - 7310
反应条件
diethyl ether
Eintragen des Reaktionsgemisches in wss. H2SO4 und anschliessend Erhitzen;
参考文献
Woods; Tucker
Journal of the American Chemical Society, 1948 , vol. 70, p. 3340
反应条件
diethyl ether
Erhitzen des erhaltenen Reaktionsprodukts mit Palladium/Kohle in p-Cymol;
参考文献
Woods et al.
Journal of the American Chemical Society, 1950 , vol. 72, p. 3221,3225, 3226
反应条件
in 1-methyl-pyrrolidin-2-one; dimethyl sulfoxide
T=80°C; 36 h;
参考文献
Izawa, Yusuke; Zheng, Changwu; Stahl, Shannon S.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 13 p. 3672 - 3675
Angew. Chem., 2013 , vol. 125, # 13 p. 3760 - 3763,4
参考文献
Woods; Tucker
Journal of the American Chemical Society, 1948 , vol. 70, p. 3340
反应条件
sodium tetrahydroborate in methanol
T=0°C; 1 h;
参考文献
Singh, Chandan; Gupta, Nitin; Puri, Sunil K.
Tetrahedron Letters, 2005 , vol. 46, # 2 p. 205 - 207
