N-Boc-L-叔亮氨酸合成路线 （共 25 条）
反应条件
1: NEt3 / tetrahydrofuran / -10 °C 2: NaBH4 / H2O / 0 °C View Scheme
参考文献
Chen, Kevin X.; Vibulbhan, Bancha; Yang, Weiying; Nair, Latha G.; Tong, Xiao; Cheng, Kuo-Chi; Njoroge, F. George
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 4 p. 1105 - 1109
反应条件
1: hydrogenchloride / toluene; water / 3 h / 60 °C 2: sodium hydroxide / water / 2 h / 25 °C / pH 10 - 13 View Scheme
参考文献
Kaneka Corporation
Patent: EP2423187 A1, 2012 ;
反应条件
1: 81 percent / N-(dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; N-methylmorpholine; 1-hydroxy-1,2,3-benzotriazole hydrate / CH2Cl2 / 2 - 20 °C
2: 97 percent / HCl(gas) / CH2Cl2; dioxane / 4 - 20 °C
3: 99 percent / N-(dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; i-Pr2NEt; 1-hydroxy-1,2,3-benzotriazole hydrate / CH2Cl2 / 4 - 20 °C
4: 80 percent / TFA / CH2Cl2 / 2 h / 20 °C
View Scheme
参考文献
Ashcroft, Christopher P.; Challenger, Stephen; Derrick, Andrew M.; Storey, Richard; Thomson, Nicholas M.
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 362 - 368
反应条件
1: 81 percent / N-(dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; N-methylmorpholine; 1-hydroxy-1,2,3-benzotriazole hydrate / CH2Cl2 / 2 - 20 °C
2: 97 percent / HCl(gas) / CH2Cl2; dioxane / 4 - 20 °C
3: 99 percent / N-(dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; i-Pr2NEt; 1-hydroxy-1,2,3-benzotriazole hydrate / CH2Cl2 / 4 - 20 °C
View Scheme
参考文献
Ashcroft, Christopher P.; Challenger, Stephen; Derrick, Andrew M.; Storey, Richard; Thomson, Nicholas M.
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 362 - 368
反应条件
1: 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide
2: hydrogenchloride / 1,4-dioxane
3: triethylamine / 1,4-dioxane
View Scheme
参考文献
Morgan, Adam J.; Nguyen, Sophia; Uttamsingh, Vinita; Bridson, Gary; Harbeson, Scott; Tung, Roger; Masse, Craig E.
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 9 p. 613 - 624
