N-Boc-L-叔亮氨酸合成路线

参考文献

Journal of Organic Chemistry, , vol. 78, # 22 p. 11229 - 11237

参考文献

Onaran, M. Burak; Comeau, Anthony B.; Seto, Christopher T.
Journal of Organic Chemistry, 2005 , vol. 70, # 26 p. 10792 - 10802

62965-35-9N-Boc-L-叔亮氨酸

20859-02-3L-叔亮氨酸

参考文献

Agosta, Eleonora; Caligiuri, Antonio; D'Arrigo, Paola; Servi, Stefano; Tessaro, Davide; Canevotti, Renato
Tetrahedron Asymmetry, 2006 , vol. 17, # 13 p. 1995 - 1999

630420-16-5Asunaprevir; (1R,2S)-N-[(1,1-二甲基乙氧基)羰基]-3-甲基-L-缬氨酰-(4R)-4-[(7-氯-4-甲氧基-1-异喹啉基)氧基]-L-脯氨酰-1-氨基-N-(环丙基磺酰基)-2-乙烯基环丙基甲酰胺

参考文献

Bristol-Myers Squibb Company
Patent: US2009/274652 A1, 2009 ;
Location in patent: Page/Page column 38; 40 ;
US 20090274652 A1

1028252-93-8+

62965-35-9N-Boc-L-叔亮氨酸

630420-16-5Asunaprevir; (1R,2S)-N-[(1,1-二甲基乙氧基)羰基]-3-甲基-L-缬氨酰-(4R)-4-[(7-氯-4-甲氧基-1-异喹啉基)氧基]-L-脯氨酰-1-氨基-N-(环丙基磺酰基)-2-乙烯基环丙基甲酰胺

参考文献

Li, Xianfeng; Zhang, Suoming; Zhang, Yong-Kang; Liu, Yang; Ding, Charles Z.; Zhou, Yasheen; Plattner, Jacob J.; Baker, Stephen J.; Bu, Wei; Liu, Liang; Kazmierski, Wieslaw M.; Duan, Maosheng; Grimes, Richard M.; Wright, Lois L.; Smith, Gary K.; Jarvest, Richard L.; Ji, Jing-Jing; Cooper, Joel P.; Tallant, Matthew D.; Crosby, Renae M.; Creech, Katrina; Ni, Zhi-Jie; Zou, Wuxin; Wright, Jon
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 2048 - 2054

62965-35-9N-Boc-L-叔亮氨酸

630420-16-5Asunaprevir; (1R,2S)-N-[(1,1-二甲基乙氧基)羰基]-3-甲基-L-缬氨酰-(4R)-4-[(7-氯-4-甲氧基-1-异喹啉基)氧基]-L-脯氨酰-1-氨基-N-(环丙基磺酰基)-2-乙烯基环丙基甲酰胺

参考文献

BRISTOL-MYERS SQUIBB COMPANY; SUN, Li-Qiang; SCOLA, Paul Michael
Patent: WO2012/166459 A1, 2012 ;
Location in patent: Page/Page column 29 ;
WO 2012/166459 A1

1169846-35-8+

62965-35-9N-Boc-L-叔亮氨酸

630420-16-5Asunaprevir; (1R,2S)-N-[(1,1-二甲基乙氧基)羰基]-3-甲基-L-缬氨酰-(4R)-4-[(7-氯-4-甲氧基-1-异喹啉基)氧基]-L-脯氨酰-1-氨基-N-(环丙基磺酰基)-2-乙烯基环丙基甲酰胺

参考文献

BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2009/85659 A1, 2009 ;
Location in patent: Page/Page column 25; 26-27 ;

1028252-17-6+

62965-35-9N-Boc-L-叔亮氨酸

630420-16-5Asunaprevir; (1R,2S)-N-[(1,1-二甲基乙氧基)羰基]-3-甲基-L-缬氨酰-(4R)-4-[(7-氯-4-甲氧基-1-异喹啉基)氧基]-L-脯氨酰-1-氨基-N-(环丙基磺酰基)-2-乙烯基环丙基甲酰胺

参考文献

Scola, Paul M.; Sun, Li-Qiang; Wang, Alan Xiangdong; Chen, Jie; Sin, Ny; Venables, Brian L.; Sit, Sing-Yuen; Chen, Yan; Cocuzza, Anthony; Bilder, Donna M.; D'Andrea, Stanley V.; Zheng, Barbara; Hewawasam, Piyasena; Tu, Yong; Friborg, Jacques; Falk, Paul; Hernandez, Dennis; Levine, Steven; Chen, Chaoqun; Yu, Fei; Sheaffer, Amy K.; Zhai, Guangzhi; Barry, Diana; Knipe, Jay O.; Han, Yong-Hae; Schartman, Richard; Donoso, Maria; Mosure, Kathy; Sinz, Michael W.; Zvyaga, Tatyana; Good, Andrew C.; Rajamani, Ramkumar; Kish, Kevin; Tredup, Jeffrey; Klei, Herbert E.; Gao, Qi; Mueller, Luciano; Colonno, Richard J.; Grasela, Dennis M.; Adams, Stephen P.; Loy, James; Levesque, Paul C.; Sun, Huabin; Shi, Hong; Sun, Lucy; Warner, William; Li, Danshi; Zhu, Jialong; Meanwell, Nicholas A.; McPhee, Fiona
Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1730 - 1752

62965-35-9N-Boc-L-叔亮氨酸

340161-31-1(2S)-2-氨基-N,N-二乙基-3,3-二甲基-丁酰胺

参考文献

Hu, Shenshen; Zhang, Long; Li, Jiuyuan; Luo, Sanzhong; Cheng, Jin-Pei
European Journal of Organic Chemistry, 2011 , # 18 p. 3347 - 3352

62965-35-9N-Boc-L-叔亮氨酸

178933-95-4L-亮氨酰-N,3-二甲基-L-缬氨酰胺

参考文献

Onaran, M. Burak; Comeau, Anthony B.; Seto, Christopher T.
Journal of Organic Chemistry, 2005 , vol. 70, # 26 p. 10792 - 10802