1: 1.) NaH / 1.) DMF, 100 deg, 0.5 h, 2.) DMF, RT, 2 h 2: 5 N aq. NaOH / methanol / 0.5 h / Heating View Scheme
参考文献
Meanwell, Nicholas A.; Rosenfeld, Michael J.; Wright, J. J. Kim; Brassard, Catherine L.; Buchanan, John O.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 389 - 397
lithium aluminium tetrahydride in diethyl ether T=0°C; 0.666667 h;
参考文献
Okada, Shuji; Matsuda, Hiro; Otsuka, Masaaki; Kikuchi, Naoto; Hayamizu, Kikuko; et al.
Bulletin of the Chemical Society of Japan, 1994 , vol. 67, # 2 p. 455 - 461
1.1: 80 percent / NaH / dimethylformamide / 12 h / 0 - 20 °C 2.1: m-CPBA / CH2Cl2 / 48 h / 0 - 20 °C 3.1: potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 0.67 h / -55 °C 3.2: tetrahydrofuran; toluene / 1 h / -55 °C View Scheme
参考文献
Dzhemilev, U. M.; Balezina, G. G.; Volkova, L. A.; Krivonogov, V. P.; Tolstikov, G. A.
Chemistry of Natural Compounds, 1980 , vol. 16, # 1 p. 82 - 85
Khimiya Prirodnykh Soedinenii, 1980 , vol. 16, # 1 p. 97 - 102
Dzhemilev, U. M.; Balezina, G. G.; Volkova, L. A.; Krivonogov, V. P.; Tolstikov, G. A.
Chemistry of Natural Compounds, 1980 , vol. 16, # 1 p. 82 - 85
Khimiya Prirodnykh Soedinenii, 1980 , vol. 16, # 1 p. 97 - 102
1: 22 g / acetonitrile / 8 h / Heating
2: 1.) potassium tert-butanolate / 1.) DMF, 20 deg C, 3h, 2.) 5h
3: LiAlH4 / diethyl ether / 3 h / Heating
4: pyridine / 10 h / Ambient temperature
View Scheme
参考文献
Dzhemilev, U. M.; Balezina, G. G.; Volkova, L. A.; Krivonogov, V. P.; Tolstikov, G. A.
Chemistry of Natural Compounds, 1980 , vol. 16, # 1 p. 82 - 85
Khimiya Prirodnykh Soedinenii, 1980 , vol. 16, # 1 p. 97 - 102
