1: With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate in toluene T=100°C; 18 h; Inert atmosphere; 2: With hydrogenchloride in water; toluene 2.5 h;

tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate in toluene T=100°C; Buchwald coupling; Inert atmosphere;

1: p-TsOH / toluene / 18 h / Heating 2: Pd2(dba)3; rac-BINAP; NaOtBu / toluene / 18 h / 100 °C 3: 17 g / aq. HCl / toluene / 2 h / 25 °C View Scheme

1: Pd2(dba)3; rac-BINAP; NaOtBu / toluene / 18 h / 100 °C 2: 17 g / aq. HCl / toluene / 2 h / 25 °C View Scheme

N-bromosuccinmide in dichloromethane T=20°C; 0.166667 h;