3-羟基-1-苯基-2-丁酮合成路线 （共 7 条）
反应条件
formic acid; triethylamine; Pd0-EnCatTM in ethyl acetate
T=23°C; 6 h; Title compound not separated from byproducts;
参考文献
Ley, Steven V.; Mitchell, Claire; Pears, David; Ramarao, Chandrashekar; Yu, Jin-Quan; Zhou, Wuzong
Organic Letters, 2003 , vol. 5, # 24 p. 4665 - 4668
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene
T=140°C; 50 h;
参考文献
Vankar, Yashwant D.; Chaudhuri, Narayan C.; Singh, Surendra P.
Synthetic Communications, 1986 , vol. 16, # 13 p. 1621 - 1626
反应条件
1: 54 percent / hydrogen peroxide; NaOH / methanol; H2O / 3.5 h / 5 - 20 °C
2: formic acid; triethylamine / Pd0-EnCatTM / ethyl acetate / 6 h / 23 °C
View Scheme
参考文献
Ley, Steven V.; Mitchell, Claire; Pears, David; Ramarao, Chandrashekar; Yu, Jin-Quan; Zhou, Wuzong
Organic Letters, 2003 , vol. 5, # 24 p. 4665 - 4668
反应条件
1)ether,reflux 2)2M HCl, room temperature, 16h; Yield given. Multistep reaction;
参考文献
Gill, Melvyn; Kiefel, Milton J.; Lally, Deborah A.
Tetrahedron Letters, 1986 , vol. 27, # 17 p. 1933 - 1934
反应条件
ketoacid decarboxylase in phosphate buffer; dimethyl sulfoxide
T=30°C; pH=6.8; Title compound not separated from byproducts.;
参考文献
Gocke, Doerte; Nguyen, Cong Luan; Pohl, Martina; Stillger, Thomas; Walter, Lydia; Mueller, Michael
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 8-9 p. 1425 - 1435
反应条件
(i) NaBH4, MeOH, (ii) aq. HCl, AcOH; Multistep reaction;
参考文献
Takeda,T. et al.
Chemistry Letters, 1977 , p. 245 - 248
反应条件
VO(OCH3)(HOCH3)(OCOCHC4H9NCHC6H2OBr2); oxygen in toluene
T=20°C; 1 h; Resolution of racemate; optical yield given as percent eeenantioselective reaction;
参考文献
Chen, Chien-Tien; Kao, Jun-Qi; Salunke, Santosh B.; Lin, Ya-Hui
Organic Letters, 2011 , vol. 13, # 1 p. 26 - 29
