甲基N-苯基-beta-丙氨酸酯合成路线 (共 11 条)
反应条件
methanesulfonic acid; phosphorous pentoxide T=130°C; 5 h; Inert atmosphere;
参考文献
Schering Corporation
Patent: US2011/312995 A1, 2011 ;
Location in patent: Page/Page column 50 ;
反应条件
1: 97 percent / pyridine / 1) cooling, 15 min, 2) reflux, 30 min 2: 92 percent / 10 percent KOH / methanol; H2O / 4 h / Ambient temperature 3: PCl5 4: 86 percent / AlCl3 / or SnCl4 View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 19, # 4 p. 297 - 300
反应条件
1: diluted hydrochloric acid; NaNO2 2: aluminium amalgam; diethyl ether 3: sodium ethylate / Behandeln mit Wasser und Essigsaeure View Scheme
参考文献
Harries; Loth
Chemische Berichte, 1896 , vol. 29, p. 517
反应条件
1: 97 percent / pyridine / 1) cooling, 15 min, 2) reflux, 30 min
2: 92 percent / 10 percent KOH / methanol; H2O / 4 h / Ambient temperature
View Scheme
参考文献
Kelkar, Prabhakar M.; Sangwan, Naresh K.; Rastogi, Shri Nivas; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 4 p. 297 - 300
反应条件
1: 97 percent / pyridine / 1) cooling, 15 min, 2) reflux, 30 min
2: 92 percent / 10 percent KOH / methanol; H2O / 4 h / Ambient temperature
3: PCl5
4: 86 percent / AlCl3 / or SnCl4
5: 94 percent / NaOCH3 / methanol / 4 h / Ambient temperature
6: 91 percent / NH2NH2*H2O / acetic acid / 8 h / Heating
View Scheme
参考文献
Kelkar, Prabhakar M.; Sangwan, Naresh K.; Rastogi, Shri Nivas; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 4 p. 297 - 300
反应条件
sodium ethanolate in ethanol
3 h; Heating;
参考文献
Coumar, Mohane Selvaraj; Wu, Jian-Sung; Leou, Jiun-Shyang; Tan, Uan-Kang; Chang, Chung-Yu; Chang, Teng-Yuan; Lin, Wen-Hsing; Hsu, John T.-A.; Chao, Yu-Sheng; Wu, Su-Ying; Hsieh, Hsing-Pang
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 5 p. 1623 - 1627
参考文献
Thayer; McElvain
Journal of the American Chemical Society, 1927 , vol. 49, p. 2865
反应条件
ethylmagnesium bromide in tetrahydrofuran
14 h;
参考文献
Kano, Shinzo; Ebata, Tsutomu; Shibuya, Shiroshi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2105 - 2111
参考文献
Ballard et al.
Chem.Penicillin, <Princeton 1949>, S. 973,977
参考文献
Southwick; Crouch
Journal of the American Chemical Society, 1953 , vol. 75, p. 3413,3416