2,6-二甲氧基-4-吡啶羧酸合成路线 （共 5 条）
反应条件
1: With sodium hydroxide
0.5 h; Heating / reflux;
2: With hydrogenchloride in water
pH=4 - 6;
参考文献
Betschart, Claudia; Lerchner, Andreas; Machauer, Rainer; Rueger, Heinrich; Tintelnot-Blomley, Marina; Veenstra, Siem Jacob
Patent: US2008/132477 A1, 2008 ;
Location in patent: Page/Page column 25 ;
反应条件
sodium methylate
T=130 - 140°C;
参考文献
McMillan et al.
Journal of the American Pharmaceutical Association (1912-1977), 1953 , vol. 42, p. 457,463
Full Text Show Details
Okajima; Seki
Yakugaku Zasshi, 1953 , vol. 73, p. 845,846, 847
Chem.Abstr., 1954 , p. 10021
反应条件
sodium methylate
T=130 - 140°C;
参考文献
McMillan et al.
Journal of the American Pharmaceutical Association (1912-1977), 1953 , vol. 42, p. 457,463
Full Text Show Details
Okajima; Seki
Yakugaku Zasshi, 1953 , vol. 73, p. 845,846, 847
Chem.Abstr., 1954 , p. 10021
反应条件
thionyl chloride; N,N-dimethyl-formamide in toluene
3 h; Reflux;
参考文献
Sumitomo Chemical Company, Limited
Patent: EP2174931 A1, 2010 ;
Location in patent: Page/Page column 33 ;
反应条件
1: SOCl2
2: ethanol; N2H4+H2O
View Scheme
参考文献
Okajima; Seki
Yakugaku Zasshi, 1953 , vol. 73, p. 845,846, 847
Chem.Abstr., 1954 , p. 10021
