1: potasse / H2O / 25 deg C, 0.5 h then 75 deg C, 0.5 h 2: 93 percent / HCl / CHCl3 3: Et3N / tetrahydrofuran / -20 - 0 °C 4: 1.) (i-C3H7)2NLi / 1.) ether, -60 deg C, 18 h, 2.) 20 deg C, 2 h, HCl View Scheme

1: potasse / H2O / 25 deg C, 0.5 h then 75 deg C, 0.5 h 2: 93 percent / HCl / CHCl3 3: Et3N / tetrahydrofuran / -20 - 0 °C 4: 1.) (i-C3H7)2NLi / 1.) ether, -60 deg C, 18 h, 2.) 20 deg C, 2 h, HCl 5: 70 percent / H2SO4 / acetone; H2O / 4 h / 45 °C View Scheme

hydrogen; palladium 10 on activated carbon T=200°C; P=51716.2 Torr; 20 h; Inert atmosphere;

l'acide para-toluene sulfonique in benzene 5 h; Heating;

1: potasse / H2O / 25 deg C, 0.5 h then 75 deg C, 0.5 h 2: 93 percent / HCl / CHCl3 3: Et3N / tetrahydrofuran / -20 - 0 °C 4: 1.) (i-C3H7)2NLi / 1.) ether, -60 deg C, 18 h, 2.) 20 deg C, 2 h, HCl 5: 87 percent / H2SO4 / acetone; H2O / 4 h / 40 - 45 °C View Scheme