5-甲氧基-2-甲基-1H-吲哚-3-甲醛合成路线 （共 8 条）
反应条件
sodium chloride in N-methyl-acetamide; methanol
参考文献
Warner-Lambert Co.
Patent: US4981865 A1, 1991 ;
US 4981865 A
反应条件
1: 1.) triton B, 2.) conc. HCl / 1.) THF, reflux, 10 h, 2.) aq. ethanol, room temp., 1 h 2: conc.H2SO4 / 1 h / Heating View Scheme
参考文献
Garuti; Giovanninetti; Bova; Chiarini
Archiv der Pharmazie, 1988 , vol. 321, # 7 p. 377 - 383
反应条件
hydrogenchloride; N-benzyl-trimethylammonium hydroxide 1.) THF, reflux, 10 h, 2.) aq. ethanol, room temp., 1 h; Multistep reaction;
参考文献
Garuti; Giovanninetti; Bova; Chiarini
Archiv der Pharmazie, 1988 , vol. 321, # 7 p. 377 - 383
反应条件
trichlorophosphate
T=0°C; Vilsmeier reaction; 0.5 h;
参考文献
Torisu, Kazuhiko; Kobayashi, Kaoru; Iwahashi, Maki; Egashira, Hiromu; Nakai, Yoshihiko; Okada, Yutaka; Nanbu, Fumio; Ohuchida, Shuichi; Nakai, Hisao; Toda, Masaaki
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 5 p. 505 - 519
反应条件
N,N-dimethyl-formamide; trichlorophosphate
T=0°C;
参考文献
Huang, Baohua; Desai, Ankur; Tang, Shengzhuang; Thomas, Thommey P.; Baker Jr., James R.
Organic Letters, 2010 , vol. 12, # 7 p. 1384 - 1387
反应条件
sodium hydroxide; trichlorophosphate in N-methyl-acetamide; water; N,N-dimethyl-formamide
参考文献
Warner-Lambert Co.
Patent: US4981865 A1, 1991 ;
US 4981865 A
反应条件
1: sodium hydride / N,N-dimethyl-formamide
2: nitric acid / acetic acid / 0 °C
3: tin; hydrogenchloride / ethanol / |Reflux
4: Fremy’s salt / acetone; aq. phosphate buffer / pH 6.4
5: sodium tetrahydroborate / methanol
View Scheme
参考文献
Sharma, Kavita; Iyer, Aishwarya; Sengupta, Kundan; Chakrapani, Harinath
Organic Letters, 2013 , vol. 15, # 11 p. 2636 - 2639
反应条件
1: ammonium acetate
2: sodium tris(acetoxy)borohydride / tetrahydrofuran
3: palladium 10 on activated carbon; ammonium formate / methanol
View Scheme
参考文献
HERCULES TECHNOLOGY MANAGEMENT CO V, INC.; BLAGG, Julian
Patent: WO2011/47156 A1, 2011 ;
WO 2011/047156 A1
