4-乙基-3,5-二甲基-1H-吡咯-2-甲醛合成路线 （共 13 条）
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate
T=0 - 20°C; Inert atmosphere;
2: 2,4-dimethyl-3-ethyl pyrrole in 1,2-dichloro-ethane
T=0°C; 0.833333 h; Reflux;
3: With water; sodium acetate in 1,2-dichloro-ethane
0.5 h; Reflux;
参考文献
Wu, Liangxing; Burgess, Kevin
Chemical Communications, 2008 , # 40 p. 4933 - 4935
反应条件
1: 100 percent / NaOH / ethane-1,2-diol / 1 h / Heating
2: 75 percent / PhCOCl / 0 - 20 °C
View Scheme
参考文献
Lash, Timothy D.; Chen, Shaohua
Tetrahedron, 2005 , vol. 61, # 49 p. 11577 - 11600
反应条件
1: H2, triethylamine / 10percent Pd/C / ethanol / 2 h
2: 100 - 102 °C / 20 - 22 Torr
3: 1.76 g / phosphoryl chloride / diethyl ether / -78 °C
View Scheme
参考文献
Clezy, Peter S.; Fookes, Christopher J. R.; Prashar, Jognandan K.
Australian Journal of Chemistry, 1989 , vol. 42, # 6 p. 775 - 786
反应条件
sodium hydrogencarbonate in water
75.7 h;
参考文献
Wijesekera, Tilak P.; Paine, John B.; Dolphin, David
Journal of Organic Chemistry, 1985 , vol. 50, # 20 p. 3832 - 3838
反应条件
1: POCl3 / CH2Cl2 / Heating
2: NaHCO3 / H2O / 75.7 h
View Scheme
参考文献
Wijesekera, Tilak P.; Paine, John B.; Dolphin, David
Journal of Organic Chemistry, 1985 , vol. 50, # 20 p. 3832 - 3838
反应条件
1: 100 - 102 °C / 20 - 22 Torr
2: 1.76 g / phosphoryl chloride / diethyl ether / -78 °C
View Scheme
参考文献
Clezy, Peter S.; Fookes, Christopher J. R.; Prashar, Jognandan K.
Australian Journal of Chemistry, 1989 , vol. 42, # 6 p. 775 - 786
反应条件
1: 60 percent / Zn, AcOH / 1 h / Heating
2: 80 percent / KOH / ethane-1,2-diol / 5 h / Heating
3: 75 percent / POCl3 / 2 h / 20 °C
View Scheme
参考文献
Berezin, M. V.; Semeikin, A. S.; V'yugin, A. I.; Krestov, G. A.
Russian Chemical Bulletin, 1993 , vol. 42, # 3 p. 449 - 453
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1993 , # 3 p. 495 - 499
反应条件
sodium hydroxide; benzoyl chloride
1.) ethylene glycol, reflux 45 min, 2.) toluene, -5-0 deg C, 1 h; Yield givenMultistep reaction;
参考文献
Lash, Timothy D.; Mani, Ukti N.; Drinan, Martin A.; Zhen, Chun; Hall, Troii; Jones, Marjorie A.
Journal of Organic Chemistry, 1999 , vol. 64, # 2 p. 464 - 477
反应条件
trifluoroacetic acid; trimethyl orthoformate
Multistep reaction;
参考文献
Clewlow, Paul J.; Jackson, Anthony H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 7 p. 1925 - 1936
反应条件
hydrogenchloride; diethyl ether; chloroform
Kochen des erhaltenen Imid-hydrochlorids mit waessrig-aelkoholischer Natronlauge;
参考文献
Fischer; Halbig; Walach
Justus Liebigs Annalen der Chemie, 1927 , vol. 452, p. 279,296, 300
