dilithium salt of (2S,5S)-2, 5-diisopropylpiperazine 1) toluene, hexane, RT, 30 min, 2) RT, 20h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
1: iodobenzene With Et2CHMgCl in tetrahydrofuran T=0°C; 0.333333 h; Inert atmosphere; 2: With methylzync chloride in tetrahydrofuran T=20°C; 0.25 h; Inert atmosphere; 3: i -Pr2Zn With iron (III) acetylacetonate; ethylene dibromide in tetrahydrofuran T=20°C; 3 h; Inert atmosphere;
参考文献
Cahiez, Gerard; Foulgoc, Laura; Moyeux, Alban
Angewandte Chemie, International Edition, 2009 , vol. 48, # 16 p. 2969 - 2972
