6-甲基-2,4(1H,3h)-喹唑啉二酮合成路线 （共 9 条）
反应条件
1: With acetic acid in water T=30°C; 2.5 h; Reflux; 2: With sodium hydroxide in water T=90°C; 1 h;
参考文献
Okano, Masahiko; Mito, Jun; Maruyama, Yasufumi; Masuda, Hirofumi; Niwa, Tomoko; Nakagawa, Shin-ichiro; Nakamura, Yoshitaka; Matsuura, Akira
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 119 - 132
参考文献
Mao, Yongjun; Lin, Nan; Tian, Wang; Han, Xiaofeng; Han, Xiaobing; Huang, Ziwei; An, Jing
Journal of Medicinal Chemistry, 2012 , vol. 55, # 3 p. 1346 - 1359
反应条件
trimethylsilylazide; iron(III) chloride in 1,2-dichloro-ethane T=20°C; azido-Schmidt reaction; 0.583333 h;
参考文献
Yadav; Reddy, B.V. Subba; Reddy, U.V. Subba; Praneeth
Tetrahedron Letters, 2008 , vol. 49, # 32 p. 4742 - 4745
反应条件
zinc(II) chloride T=200°C; 5 h; sealed tube;
参考文献
Jiarong, Li; Xian, Chen; Daxin, Shi; Shuling, Ma; Qing, Li; Qi, Zhang; Jianhong, Tang
Organic Letters, 2009 , vol. 11, # 6 p. 1193 - 1196
反应条件
TBA2[WO4] in dimethyl sulfoxide T=99.84°C; P=750.075 Torr; 12 h; Schlenk technique; Catalytic behavior; PressureTime;
参考文献
Kimura, Toshihiro; Sunaba, Hanako; Kamata, Keigo; Mizuno, Noritaka
Inorganic Chemistry, 2012 , vol. 51, # 23 p. 13001 - 13008
反应条件
acetic acid; sodium nitrite in water 0.25 h; Ambient temperature;
参考文献
Lalezari, Iraj; Stein, C. A.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 1 p. 5 - 7
反应条件
zinc(II) chloride T=200°C; 5 h; sealed tube;
参考文献
Jiarong, Li; Xian, Chen; Daxin, Shi; Shuling, Ma; Qing, Li; Qi, Zhang; Jianhong, Tang
Organic Letters, 2009 , vol. 11, # 6 p. 1193 - 1196
反应条件
N-ethyl-N,N-diisopropylamine; trichlorophosphate 3 h; Reflux;
参考文献
Smits, Rogier A.; Lim, Herman D.; Van Der Meer, Tiffany; Kuhne, Sebastiaan; Bessembinder, Karin; Zuiderveld, Obbe P.; Wijtmans, Maikel; De Esch, Iwan J.P.; Leurs, Rob
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 461 - 467
反应条件
1: 77 percent / phosphorous oxychloride; N,N-dimethylaniline / 5 h / 115 °C
2: 95 percent / sodium hydroxide / H2O / 3 h / 30 °C
View Scheme
参考文献
Ram, Vishnu Ji; Farhanullah; Tripathi, Brajendra K.; Srivastava, Arvind K.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 11 p. 2439 - 2444
