1,5-脱水-2,3-双脱氧-3-[[(1R,3S)-3-[[7,8-二氢-3-(三氟甲基)-1,6-萘啶-6(5H)-基]羰基]-3-(1-甲基乙基)环戊基]氨基]-4-O-甲基-D-赤式-戊糖醇合成路线 (共 3 条)
反应条件
hydrogen; palladium on activated carbon in methanol T=25°C; P=2068.65 Torr; 18 h;
参考文献
MERCK and CO., INC.?
Patent: WO2005/44795 A1, 2005 ;
Location in patent: Page/Page column 4; 16 ;
WO 2005/044795 A1
反应条件
sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; Molecular sieve;
参考文献
WO2003/93266 A1, ;
Page/Page column 34-35 ;
WO 03/093266 A1
反应条件
potassium carbonate in isopropanol acetate; water 0.25 h;
参考文献
WO2005/44264 A1, ;
Page/Page column 16-17 ;
WO 2005/044264 A1