4-氯-n-甲基吡啶-3-羧酰胺合成路线 （共 2 条）
反应条件
1: 4-chloro nicotinic acid With oxalyl dichloride in DMF (N,N-dimethyl-formamide); dichloromethane
T=20°C; 1 h;
2: methylamine With triethylamine in tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane
T=0°C; 0.333333 h;
参考文献
Pfizer Limited; Pfizer Inc.
Patent: WO2004/16593 A1, 2004 ;
Location in patent: Page 33; 34 ;
WO 2004/016593 A1
反应条件
in tetrahydrofuran
T=0 - 20°C; 1 h;
参考文献
Novartis AG
Patent: US2008/45528 A1, 2008 ;
Location in patent: Page/Page column 100-101 ;
