3,3-二甲基-1-丁基酸酯合成路线 （共 65 条）
反应条件
1: NaOH / H2O / 1 h / 50 °C
2: P(OEt)3
3: N2O4 / CHCl3 / 0 °C
View Scheme
参考文献
Cooper; Lawston; Rickard; Inch
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 3 p. 207 - 212
反应条件
nickel
T=210 - 225°C; P=73550.8 Torr; Hydrogenation;
参考文献
Ipatieff et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 553
反应条件
T=220°C; P=73550.8 Torr; Produkt5: Aethan;
参考文献
Ipatieff et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 553
反应条件
1: Et3N / CH2Cl2 / 0.5 h / -50 °C
2: neat (no solvent) / 120 °C
3: 1.) BuLi, 2.) O2 / 1.) THF, 2.) -40 deg C
View Scheme
参考文献
Angelis, Yiannis S.; Orfanopoulos, Michael
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 6083 - 6085
反应条件
3: BuLi, molecular oxygen / tetrahydrofuran
View Scheme
参考文献
Angelis, Yiannis; Zhang, Xiaojun; Orfanopoulos, Michael
Tetrahedron Letters, 1996 , vol. 37, # 33 p. 5991 - 5994
