1-fluoro-pyridinium tetrafluoroborate; palladium diacetate in acetonitrile T=150°C; 2 h; microwave irradiation;

copper(l) iodide; oxygen; acetic acid in dimethyl sulfoxide T=100°C; 24 h;

in tetrahydrofuran T=20°C; 0.5 h; Inert atmosphere;

1: ortho-fluorobromobenzene With magnesium in tetrahydrofuran Inert atmosphere; 2: 2-pyridine carbonitrile in tetrahydrofuran T=0°C; Inert atmosphere; 3: With hydrogenchloride; water in diethyl ether 0.5 h; Inert atmosphere;

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - -50 °C / Inert atmosphere 1.2: 2 h / -50 °C / Inert atmosphere 1.3: Inert atmosphere 2.1: palladium (II) trifluoroacetate; caesium carbonate; tri-cyclo-hexyl-phosphine / o-xylene; toluene / 6 h / Inert atmosphere; Reflux 3.1: copper(l) iodide; oxygen; acetic acid / dimethyl sulfoxide / 24 h / 100 °C View Scheme

1: palladium (II) trifluoroacetate; caesium carbonate; tri-cyclo-hexyl-phosphine / o-xylene; toluene / 6 h / Inert atmosphere; Reflux 2: copper(l) iodide; oxygen; acetic acid / dimethyl sulfoxide / 24 h / 100 °C View Scheme

manganese(IV) oxide 2.) ether; Yield given. Multistep reaction;