1-乙酰基-6-氨基吲哚合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; 1.4 h;
参考文献
Yamada, Yaeko; Akiba, Ai; Arima, Shiho; Okada, Chiharu; Yoshida, Kiminari; Itou, Fumihiro; Kai, Toshitsugu; Satou, Toshiko; Takeda, Kazuyoshi; Harigaya, Yoshihiro
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 10 p. 1277 - 1290
反应条件
1: 80 percent / HNO3; H2SO4 / 20 °C 2: 95 percent / 160 °C 3: 95 percent / H2 / Pd/C / methanol / 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 40, # 2 p. 167 - 172
反应条件
1: 96 percent / pyridine / 1.4 h / 20 °C 2: 100 percent / H2 / Pd/C / methanol / 1.4 h / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 53, # 10 p. 1277 - 1290
反应条件
1: 6-nitro-indoline; acetic anhydride 2: With hydrogen; palladium on activated charcoal in methanol
参考文献
Heteroatom Chemistry, , vol. 16, # 1 p. 39 - 43
反应条件
1: 1.) NaNO2 2: 86 percent View Scheme
参考文献
Yamada, Koji; Somei, Masanori
Heterocycles, 1998 , vol. 48, # 12 p. 2481 - 2484
反应条件
potassium hydroxide; acetic acid; sodium nitrite in tetrahydrofuran; methanol; sulfuric acid; water; ethyl acetate
参考文献
Pfizer Inc.
Patent: US5736534 A1, 1998 ;
反应条件
1: 62 percent / aq. NaNO2; AcOH; KI / 24 h / 0 °C 2: 71 percent / aq. NaOH / methanol / 4.5 h / 75 °C View Scheme
参考文献
Ohta, Toshiharu; Yamato, Yoshinori; Tahira, Hiroko; Somei, Masanori
Heterocycles, 1987 , vol. 26, # 11 p. 2817 - 2822
反应条件
1: 62 percent / aq. NaNO2; AcOH; KI / 24 h / 0 °C 2: 71 percent / aq. NaOH / methanol / 4.5 h / 75 °C 3: 98 percent / salcomine; O2 / methanol / 3.5 h / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 53, # 10 p. 1277 - 1290
反应条件
acetic acid; potassium iodide; sodium nitrite T=0°C; 24 h;
参考文献
Yamada, Yaeko; Akiba, Ai; Arima, Shiho; Okada, Chiharu; Yoshida, Kiminari; Itou, Fumihiro; Kai, Toshitsugu; Satou, Toshiko; Takeda, Kazuyoshi; Harigaya, Yoshihiro
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 10 p. 1277 - 1290
反应条件
copper(I) bromide; hydrogenchloride; sodium nitrite
Yield given. Multistep reaction;
参考文献
Ohta, Toshiharu; Yamato, Yoshinori; Tahira, Hiroko; Somei, Masanori
Heterocycles, 1987 , vol. 26, # 11 p. 2817 - 2822
