1 -甲基- 1H-咪唑-2 -羧酸甲酯合成路线 （共 5 条）
反应条件
in methanol; water 1) 0 deg C, 5 h; 2) room temperature, overnight;
参考文献
Bakhtiar, Cuross; Smith, Edward H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 3 p. 239 - 244
反应条件
1: 1-methyl-1H-imidazole With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=-78 - 20°C; 2 h;
3: methanol Further stages;
参考文献
Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 24 p. 4701 - 4709
反应条件
N-bromosuccinmide in tetrahydrofuran
T=-10 - 20°C; 14 h;
参考文献
SPIROGEN LIMITED
Patent: WO2005/85177 A2, 2005 ;
Location in patent: Page/Page column 61-62 ;
反应条件
in tetrahydrofuran; hexane
12 h; Ambient temperature; Yield given;
参考文献
Bakhtiar, Cuross; Smith, Edward H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 3 p. 239 - 244
反应条件
n-butyllithium
1.) hexane, Et2O, reflux, 5.5 h, 2.) -78 deg C, 3 h then room temp., 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Carpenter, Andrew J.; Chadwick, Derek J.; Ngochindo Raphael I.
Journal of Chemical Research, Miniprint, 1983 , # 8 p. 1913 - 1941
