甘露糖酸-delta-内酰胺合成路线 （共 23 条）
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; Hydrolysis; 6 h;
参考文献
Nishimura, Yoshio; Adachi, Hayamitsu; Satoh, Takahiko; Shitara, Eiki; Nakamura, Hikaru; Kojima, Fukiko; Takeuchi, Tomio
Journal of Organic Chemistry, 2000 , vol. 65, # 16 p. 4871 - 4882
反应条件
hydrogenchloride; hydrogen; palladium dihydroxide; palladium on activated charcoal in methanol; ethanol 48 h;
参考文献
Overkleeft, Herman S.; Wiltenburg, Jim van; Pandit, Upendra K.
Tetrahedron, 1994 , vol. 50, # 14 p. 4215 - 4224
反应条件
trifluoroacetic acid in water T=20°C; 10 h;
参考文献
Knight, Julian G.; Tchabanenko, Kirill
Tetrahedron, 2003 , vol. 59, # 3 p. 281 - 286
反应条件
1.1: (n-Bu)2SnO; MS 4A / benzene / Heating 1.2: 97 percent / iPr2NEt / dimethylformamide / 3 h / 20 °C 2.1: pyridine / CH2Cl2 / 2 h / -40 °C 3.1: NaN3 / dimethylformamide / 20 °C 4.1: 65 percent / H2 / Raney Ni / methanol / 4 h / 20 °C 5.1: 68 percent / 4M HCl / dioxane / 6 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 16 p. 4871 - 4882
反应条件
trifluoroacetic acid in water 1 h;
参考文献
Fleet, George W. J.; Ramsden, Nigel G.; Witty, David R.
Tetrahedron, 1989 , vol. 45, # 1 p. 319 - 326
反应条件
1: 1.) HCl, 2.) AcOH / 2.) H2O 2: 95 percent / pyridine 3: 92 percent / pyridine / CH2Cl2 4: 76 percent / n-Bu4NN3 / tetrahydrofuran 5: 88 percent / H2 / Pd(OH)2 / ethyl acetate 6: 85 percent / TFA / H2O View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 18 p. 1221
反应条件
trifluoroacetic acid in water
参考文献
Shing, Tony K. M.
Journal of the Chemical Society, Chemical Communications, 1988 , # 18 p. 1221
反应条件
1: 65 percent / H2 / Raney Ni / methanol / 4 h / 20 °C 2: 68 percent / 4M HCl / dioxane / 6 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 16 p. 4871 - 4882
反应条件
1: pyridine / CH2Cl2 / 2 h / -40 °C 2: NaN3 / dimethylformamide / 20 °C 3: 65 percent / H2 / Raney Ni / methanol / 4 h / 20 °C 4: 68 percent / 4M HCl / dioxane / 6 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 16 p. 4871 - 4882
反应条件
1: NaN3 / dimethylformamide / 20 °C 2: 65 percent / H2 / Raney Ni / methanol / 4 h / 20 °C 3: 68 percent / 4M HCl / dioxane / 6 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 16 p. 4871 - 4882
